A Survival Guide to Early T Cell Development

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2006 Jun 9

PMID 16760572

Citations 27

Authors

Maria Ciofani

Juan Carlos Zuniga-Pflucker

Affiliations

Soon will be listed here.

Abstract

The survival of immature T cell precursors is dependent on both thymus-derived extrinsic signals and self-autonomous pre-TCR-mediated signals. While the role of cytokines and the pre-TCR in promoting thymocyte survival has been well established, the relationship between pro- and anti-apoptotic signaling cascades remains poorly defined. Recent studies have established a link between cell survival and growth factor-mediated maintenance of cellular metabolism. In this regard, the Notch signaling pathway has emerged as more than an inducer of T lineage commitment and differentiation, but also as a potent trophic factor, promoting the survival and metabolic state of pre-T cells. In this review, we describe current concepts of the intracellular signaling pathways downstream of cell intrinsic and extrinsic factors that dictate survival versus death outcomes during early T cell development.

Citing Articles

Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells.

Guo R, Li W, Li Y, Li Y, Jiang Z, Song Y Exp Hematol Oncol. 2022; 11(1):27.

PMID: 35568954 PMC: 9107657. DOI: 10.1186/s40164-022-00285-y.

How transcription factors drive choice of the T cell fate.

Hosokawa H, Rothenberg E Nat Rev Immunol. 2020; 21(3):162-176.

PMID: 32918063 PMC: 7933071. DOI: 10.1038/s41577-020-00426-6.

Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage.

Bai L, Shi G, Ma Y, Zhang L, Guan F, Zhang X Sci Rep. 2018; 8(1):14457.

PMID: 30262871 PMC: 6160460. DOI: 10.1038/s41598-018-32780-w.

Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands.

Das D, Mallis R, Duke-Cohan J, Hussey R, Tetteh P, Hilton M J Biol Chem. 2016; 291(49):25292-25305.

PMID: 27707880 PMC: 5207233. DOI: 10.1074/jbc.M116.752865.

Thymic DCs derived IL-27 regulates the final maturation of CD4(+) SP thymocytes.

Tang H, Zhang J, Sun X, Qian X, Zhang Y, Jin R Sci Rep. 2016; 6:30448.

PMID: 27469302 PMC: 5387111. DOI: 10.1038/srep30448.

References

Rathmell J, Farkash E, Gao W, Thompson C . IL-7 enhances the survival and maintains the size of naive T cells. J Immunol. 2001; 167(12):6869-76. DOI: 10.4049/jimmunol.167.12.6869. View

Capone M, Hockett Jr R, Zlotnik A . Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes. Proc Natl Acad Sci U S A. 1998; 95(21):12522-7. PMC: 22863. DOI: 10.1073/pnas.95.21.12522. View

Whetton A, BAZILL G, Dexter T . Haemopoietic cell growth factor mediates cell survival via its action on glucose transport. EMBO J. 1984; 3(2):409-13. PMC: 557359. DOI: 10.1002/j.1460-2075.1984.tb01821.x. View

Opferman J, Letai A, Beard C, Sorcinelli M, Ong C, Korsmeyer S . Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003; 426(6967):671-6. DOI: 10.1038/nature02067. View

Malissen M, Pereira P, Gerber D, Malissen B, DiSanto J . The common cytokine receptor gamma chain controls survival of gamma/delta T cells. J Exp Med. 1997; 186(8):1277-85. PMC: 2199080. DOI: 10.1084/jem.186.8.1277. View

Talora C, Campese A, Bellavia D, Pascucci M, Checquolo S, Groppioni M . Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep. 2003; 4(11):1067-72. PMC: 1326383. DOI: 10.1038/sj.embor.embor7400013. View

Moore T, Murray R, Zlotnik A . Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice. J Immunol. 1996; 157(6):2366-73. View

Raff M . Social controls on cell survival and cell death. Nature. 1992; 356(6368):397-400. DOI: 10.1038/356397a0. View

Bellavia D, Campese A, Alesse E, Vacca A, Felli M, Balestri A . Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 2000; 19(13):3337-48. PMC: 313949. DOI: 10.1093/emboj/19.13.3337. View

10.

Matsuzaki Y, Nakayama K, Tomita T, ISODA M, Loh D, Nakauchi H . Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood. 1997; 89(3):853-62. View

11.

Michie A, Zuniga-Pflucker J . Regulation of thymocyte differentiation: pre-TCR signals and beta-selection. Semin Immunol. 2002; 14(5):311-23. DOI: 10.1016/s1044-5323(02)00064-7. View

12.

Chao D, Korsmeyer S . BCL-XL-regulated apoptosis in T cell development. Int Immunol. 1997; 9(9):1375-84. DOI: 10.1093/intimm/9.9.1375. View

13.

Fox C, Hammerman P, Thompson C . Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol. 2005; 5(11):844-52. DOI: 10.1038/nri1710. View

14.

Pekarsky Y, Hallas C, Palamarchuk A, Koval A, Bullrich F, Hirata Y . Akt phosphorylates and regulates the orphan nuclear receptor Nur77. Proc Natl Acad Sci U S A. 2001; 98(7):3690-4. PMC: 31113. DOI: 10.1073/pnas.051003198. View

15.

Pallard C, Stegmann A, van Kleffens T, Smart F, Venkitaraman A, Spits H . Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity. 1999; 10(5):525-35. DOI: 10.1016/s1074-7613(00)80052-7. View

16.

Van De Wiele C, Marino J, Murray B, Vo S, Whetsell M, Teague T . Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol. 2004; 172(7):4235-44. DOI: 10.4049/jimmunol.172.7.4235. View

17.

Godfrey D, Kennedy J, Mombaerts P, Tonegawa S, Zlotnik A . Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol. 1994; 152(10):4783-92. View

18.

Rodewald H, Ogawa M, Haller C, Waskow C, DiSanto J . Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Immunity. 1997; 6(3):265-72. DOI: 10.1016/s1074-7613(00)80329-5. View

19.

Durum S, Candeias S, Nakajima H, Leonard W, Baird A, Berg L . Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. J Exp Med. 1998; 188(12):2233-41. PMC: 2212428. DOI: 10.1084/jem.188.12.2233. View

20.

Stupack D, Cheresh D . Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci. 2002; 115(Pt 19):3729-38. DOI: 10.1242/jcs.00071. View