Bactericidal and Cyclooxygenase Inhibitory Diterpenes from Eremophila Sturtii

Overview

Journal Phytochemistry

Publisher Elsevier

Specialties Biochemistry
Biology
Chemistry

Date 2006 Jun 9

PMID 16759677

Citations 9

Authors

Qian Liu

David Harrington

James L Kohen

Subramanyam Vemulpad

Joanne F Jamie

Affiliations

Soon will be listed here.

Abstract

Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.

Citing Articles

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Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas.

Semple S, Staerk D, Buirchell B, Fowler R, Gericke O, Kjaerulff L Plant J. 2022; 111(4):936-953.

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The Diversity of Volatile Compounds in Australia's Semi-Desert Genus (Scrophulariaceae).

Sadgrove N, Padilla-Gonzalez G, Green A, Langat M, Mas-Claret E, Lyddiard D Plants (Basel). 2021; 10(4).

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Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species.

Gericke O, Hansen N, Pedersen G, Kjaerulff L, Luo D, Staerk D BMC Plant Biol. 2020; 20(1):91.

PMID: 32111159 PMC: 7049213. DOI: 10.1186/s12870-020-2293-x.