Role of SUMO/Ubc9 in DNA Damage Repair and Tumorigenesis

Overview

Journal J Mol Histol

Specialty Biochemistry

Date 2006 Jun 8

PMID 16758298

Citations 16

Authors

Stergios J Moschos

Yin-Yuan Mo

Affiliations

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Abstract

DNA damage repair is an important cell function for genome integrity and its deregulation can lead to genomic instability and development of malignancies. Sumoylation is an increasingly important ubiquitin-like modification of proteins affecting protein stability, enzymatic activity, nucleocytoplasmic trafficking, and protein-protein interactions. In particular, several important DNA repair enzymes are subject to sumoylation, which appears to play a role in copping with DNA damage insults. Recent reports indicate that Ubc9, the single SUMO E2 enzyme catalyzing the conjugation of SUMO to target proteins, is overexpressed in certain tumors, such as lung adenocarcinoma, ovarian carcinoma and melanoma, suggestive of its clinic significance. This review summarizes the most important DNA damage repair pathways which are potentially affected by Ubc9/SUMO and their role in regulating the function of several proteins involved in the DNA damage repair machinery.

Citing Articles

Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression.

Wang Y, Zou H, Ji W, Huang M, You B, Sun N Cancer Biol Ther. 2024; 25(1):2323768.

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An Update on the Role of Ubiquitination in Melanoma Development and Therapies.

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Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators.

Wessel S, Mohni K, Luzwick J, Dungrawala H, Cortez D Cell Rep. 2019; 28(13):3497-3509.e4.

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Variation in expression of small ubiquitin-like modifiers in injured sciatic nerve of mice.

Zhang D, Yu K, Yang Z, Liu X, Ma X, Li Y Neural Regen Res. 2019; 14(8):1455-1461.

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Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.

Francois-Moutal L, Dustrude E, Wang Y, Brustovetsky T, Dorame A, Ju W Pain. 2018; 159(10):2115-2127.

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