Differential Effects of Clorgyline on Sensitization to Quinpirole in Rats Tested in Small and Large Environments

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2006 Jun 8

PMID 16758240

Citations 5

Authors

Anna Dvorkin

Kirsten E Culver

Henry Szechtman

Affiliations

Soon will be listed here.

Abstract

Rationale: Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity chambers. However, like with other psychostimulant drugs, sensitization to quinpirole is modulated by environmental context. It is not known whether the clorgyline cotreatment effect is likewise influenced by the environment.

Objective: To determine the generality of the clorgyline effect on behavioral sensitization by evaluating the effects of clorgyline cotreatment on sensitization to quinpirole in two different environments: a small activity chamber and a large open field.

Methods: Male rats received eight injections of quinpirole (0.5 mg/kg, twice weekly) in an open field or activity chamber; one group in each environment received a constant infusion of clorgyline (1 mg/kg/day via osmotic minipumps) while the other group served as the sham surgery control. For quinpirole injection 7 or 8, rats were tested in the alternate environment.

Results: In activity chambers, clorgyline cotreatment switched sensitization to quinpirole from locomotion to mouthing. In the open field, clorgyline cotreatment increased mouthing and expanded the explored space without a change in path stereotypy or the amount of locomotion compared to treatment with quinpirole alone.

Conclusions: Structure of the environment can modulate the clorgyline cotreatment effect on behavioral sensitization to quinpirole. The behavioral profiles produced by clorgyline cotreatment in the two environments resembled the behavioral effects observed with quinpirole and D1 agonist cotreatment. It is suggested that clorgyline cotreatment produces a behavioral profile characteristic of enhanced dopamine D1 and D2 receptor costimulation.

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References

Lee S, So C, Rashid A, Varghese G, Cheng R, Lanca A . Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. J Biol Chem. 2004; 279(34):35671-8. DOI: 10.1074/jbc.M401923200. View

Culver K, Rosenfeld J, Szechtman H . Monoamine oxidase inhibitor-induced blockade of locomotor sensitization to quinpirole: role of striatal dopamine uptake inhibition. Neuropharmacology. 2002; 43(3):385-93. DOI: 10.1016/s0028-3908(02)00128-4. View

Ventura M . Effects of clorgyline and deprenil on corticosterone levels in rats. Eur J Pharmacol. 1982; 81(3):349-55. DOI: 10.1016/0014-2999(82)90099-1. View

Culver K, Szechtman H . Hypophysectomy does not block sensitization to the dopamine agonist quinpirole or its modulation by the MAOI clorgyline. Horm Behav. 2004; 45(1):23-30. DOI: 10.1016/j.yhbeh.2003.07.004. View

Imperato A, Tanda G, Frau R, Di Chiara G . Pharmacological profile of dopamine receptor agonists as studied by brain dialysis in behaving rats. J Pharmacol Exp Ther. 1988; 245(1):257-64. View

Itzhak Y, Mash D, Zhang S, Stein I . Characterization of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) binding sites in C57BL/6 mouse brain: mutual effects of monoamine oxidase inhibitors and sigma ligands on MPTP and sigma binding sites. Mol Pharmacol. 1991; 39(3):385-93. View

Culver K, Rosenfeld J, Szechtman H . A switch mechanism between locomotion and mouthing implicated in sensitization to quinpirole in rats. Psychopharmacology (Berl). 2000; 151(2-3):202-10. DOI: 10.1007/s002139900346. View

Szechtman H, Culver K, Eilam D . Role of dopamine systems in obsessive-compulsive disorder (OCD): implications from a novel psychostimulant-induced animal model. Pol J Pharmacol. 1999; 51(1):55-61. View

Culver K, Szechtman H . Clorgyline-induced switch from locomotion to mouthing in sensitization to the dopamine D2/D3 agonist quinpirole in rats: role of sigma and imidazoline I2 receptors. Psychopharmacology (Berl). 2003; 167(2):211-8. DOI: 10.1007/s00213-003-1408-z. View

10.

Drai D, Benjamini Y, Golani I . Statistical discrimination of natural modes of motion in rat exploratory behavior. J Neurosci Methods. 2000; 96(2):119-31. DOI: 10.1016/s0165-0270(99)00194-6. View

11.

Noldus L, Spink A, Tegelenbosch R . EthoVision: a versatile video tracking system for automation of behavioral experiments. Behav Res Methods Instrum Comput. 2001; 33(3):398-414. DOI: 10.3758/bf03195394. View

12.

Drai D, Golani I . SEE: a tool for the visualization and analysis of rodent exploratory behavior. Neurosci Biobehav Rev. 2001; 25(5):409-26. DOI: 10.1016/s0149-7634(01)00022-7. View

13.

Eilam D, Clements K, Szechtman H . Differential effects of D1 and D2 dopamine agonists on stereotyped locomotion in rats. Behav Brain Res. 1991; 45(2):117-24. DOI: 10.1016/s0166-4328(05)80077-4. View

14.

Levant B, Moehlenkamp J, Morgan K, Leonard N, Cheng C . Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site. J Pharmacol Exp Ther. 1996; 278(1):145-53. View

15.

Lai J, Leung T, Guest J, Lim L, Davison A . The monoamine oxidase inhibitors clorgyline and L-deprenyl also affect the uptake of dopamine, noradrenaline and serotonin by rat brain synaptosomal preparations. Biochem Pharmacol. 1980; 29(20):2763-7. DOI: 10.1016/0006-2952(80)90009-x. View

16.

Greenshaw A . Osmotic mini-pumps: a convenient program for weight-adjusted filling concentrations. Brain Res Bull. 1986; 16(5):759-61. DOI: 10.1016/0361-9230(86)90150-4. View

17.

Levant B, Morgan K, Grandy D, Chen K, Shih J, Seif I . Modulation of [3H]quinpirole binding at striatal D2 dopamine receptors by a monoamine oxidaseA-like site: evidence from radioligand binding studies and D2 receptor- and MAO(A)-deficient mice. Life Sci. 2002; 70(2):229-41. DOI: 10.1016/s0024-3205(01)01400-x. View

18.

Drai D, Kafkafi N, Benjamini Y, Elmer G, Golani I . Rats and mice share common ethologically relevant parameters of exploratory behavior. Behav Brain Res. 2001; 125(1-2):133-40. DOI: 10.1016/s0166-4328(01)00290-x. View

19.

Lione L, Nutt D, Hudson A . Characterisation and localisation of [3H]2-(2-benzofuranyl)-2-imidazoline binding in rat brain: a selective ligand for imidazoline I2 receptors. Eur J Pharmacol. 1998; 353(1):123-35. DOI: 10.1016/s0014-2999(98)00389-6. View

20.

Szechtman H, Dai H, Mustafa S, Einat H, Sullivan R . Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole. Pharmacol Biochem Behav. 1994; 48(4):921-8. DOI: 10.1016/0091-3057(94)90201-1. View