B Cells and B Cell Products-helping to Restore Cellular Immunity?

Overview

Journal Transfus Med Hemother

Specialty Hematology

Date 2006 Jun 7

PMID 16755301

Authors

Marilia Cascalho

Jeffrey L Platt

Affiliations

Soon will be listed here.

Abstract

T cells that provide vital protection against tumors, viruses and intracellular bacteria are thought to develop independently of B cells. However, recent discoveries suggest that development of T cells depends on B cells. One way B cells promote T cell development is by providing diverse peptides that may promote positive selection of thymocytes. Diverse peptides and B cells help in diversification of the T cell receptor repertoire and may decrease cross-reactivity in the mature T cell compartment. These new insights may provide the basis for the design of novel therapeutics.

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