An Improved Resolution Structure of the Human Beta Common Receptor Involved in IL-3, IL-5 and GM-CSF Signalling Which Gives Better Definition of the High-affinity Binding Epitope

Overview

Journal Acta Crystallogr Sect F Struct Biol Cryst Commun

Date 2006 Jun 7

PMID 16754968

Citations 10

Authors

P D Carr

F Conlan

S Ford

D L Ollis

I G Young

Affiliations

Soon will be listed here.

Abstract

X-ray diffraction has been used to produce and refine a model of the extracellular domains of the beta common cytokine receptor. A minor improvement in resolution has resulted in improved electron-density maps, which have given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule.

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