Genetic Analysis of Autoimmune Type 1 Diabetes Mellitus in Mice

Overview

Journal Nature

Specialty Science

Date 1991 Jun 13

PMID 1675432

Citations 139

Authors

J A Todd

T J Aitman

R J Cornall

S Ghosh

J R Hall

C M Hearne

A M Knight

J M Love

M A McAleer

J B Prins

Affiliations

Soon will be listed here.

Abstract

Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.

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