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Effect of Salicylate on Oxidative Phosphorylation and Respiration of Mitochondrial Fragments

Overview
Journal Biochem J
Specialty Biochemistry
Date 1965 Oct 1
PMID 16749103
Citations 15
Authors
J T Miyahara
R Karler
Affiliations
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Abstract

1. The effects of salicylate on oxidative phosphorylation and respiration were investigated in liver and brain mitochondria, and in sonically prepared mitochondrial fragments. 2. Salicylate was shown to uncouple oxidative phosphorylation in mitochondrial fragments, as well as in intact mitochondria. The effects of salicylate on mitochondria and oxidative phosphorylation resemble those produced by dinitrophenol. 3. The quantitative effects of salicylate on respiration in vitro were shown to be complex. The final effect may be the resultant of an interaction of a multiplicity of factors, such as the tissue, the substrate, mitochondrial and extramitochondrial influences, and the direct effect on the respiratory chain itself.

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References
1.
Cooper C, Lehninger A . Oxidative phosphorylation by an enzyme complex from extracts of mitochondria. I. The span beta-hydroxybutyrate to oxygen. J Biol Chem. 1956; 219(1):489-506. View
2.
BRODY T . Action of sodium salicylate and related compounds on tissue metabolism in vitro. J Pharmacol Exp Ther. 1956; 117(1):39-51. View
3.
KALNITSKY G, PENNIALL R, ROUTH J . The effects of salicylic acid and related compounds on in vitro rat brain respiration. Arch Biochem Biophys. 1956; 64(2):390-400. DOI: 10.1016/0003-9861(56)90283-1. View
4.
KIELLEY W, BRONK J . Oxidative phosphorylation in sonic extracts of rat liver mitochondria. Biochim Biophys Acta. 1957; 23(2):448-9. DOI: 10.1016/0006-3002(57)90360-8. View
5.
DRYER R, TAMMES A, ROUTH J . The determination of phosphorus and phosphatase with N-phenyl-p-phenylenediamine. J Biol Chem. 1957; 225(1):177-83. View