Studies in Detoxication: On the Alleged Formation of P-hydroxylaminobenzenesulphonamide and P-aminophenol from Sulphanilamide in Vivo, on the Colour Reactions Used for Their Detection, and on the Possible Formation of Aminophenolsulphonamides

Overview

Journal Biochem J

Specialty Biochemistry

Date 1941 Jan 1

PMID 16747388

Citations 10

Authors

W V THORPE

R T Williams

J Shelswell

Affiliations

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Citing Articles

The fate of certain organic acids and amides in the rabbit: 2. p-Hydroxybenzoic acid and its amide.

BRAY H, RYMAN B, THORPE W Biochem J. 1947; 41(2):212-8.

PMID: 16748144 PMC: 1258459.

The metabolism of sulphapyridine in the rabbit.

BRAY H, NEALE F, THORPE W Biochem J. 1946; 40(3):406-13.

PMID: 16748023 PMC: 1258363. DOI: 10.1042/bj0400406.

The metabolism of sulphonamides: 2. The isolation and identification of 3-hydroxysulphanilamide as the oxidation product of sulphanilamide in the rabbit.

Williams R Biochem J. 1946; 40(2):219-22.

PMID: 16747988 PMC: 1258323. DOI: 10.1042/bj0400219.

Studies in detoxication: The identification of catechol-4-sulphonamide as a metabolic product of p-hydroxybenzenesulphonamide in the rabbit. The synthesis of derivatives of catecholsulphonamide.

Williams R Biochem J. 1941; 35(10-11):1169-74.

PMID: 16747401 PMC: 1265620. DOI: 10.1042/bj0351169.

Studies in detoxication: The synthesis of some possible biological oxidation products of sulphanilamide.

THORPE W, Williams R Biochem J. 1941; 35(1-2):61-5.

PMID: 16747389 PMC: 1265470. DOI: 10.1042/bj0350061.

References

MacGregor R, THORPE W . The quantitative extraction of histamine from tissues by electrodialysis. Biochem J. 1933; 27(5):1394-9. PMC: 1253041. DOI: 10.1042/bj0271394. View

Brownlee G . The role of the aromatic amino group in deranged pigment metabolism. Biochem J. 1939; 33(5):697-708. PMC: 1264434. DOI: 10.1042/bj0330697. View

Rimington C, Hemmings A . Porphyrinuric action of drugs related to sulphanilamide. Comparison with reported toxicity, therapeutic efficiency and causation of methaemoglobinaemia. Definition of the structure responsible for porphyrinuric action. Biochem J. 1939; 33(6):960-77. PMC: 1264472. DOI: 10.1042/bj0330960. View

James G . The effect of administration of an acetate on detoxication and therapeutic activity of sulphanilamide. Biochem J. 1939; 33(10):1688-93. PMC: 1264633. DOI: 10.1042/bj0331688. View

Shelswell J, Williams R . Studies in detoxication: Ethereal sulphate formation in the rabbit after administration of sulphanilamide. Biochem J. 1940; 34(4):528-31. PMC: 1265308. DOI: 10.1042/bj0340528. View