Etiological Investigation of Fatal Liver Failure During the Course of Chronic Hepatitis B in Southeast China

Overview

Journal J Gastroenterol

Specialty Gastroenterology

Date 2006 Jun 3

PMID 16741614

Citations 15

Authors

Wei-Min Ke

Xue-Jun Li

Li-Na Yu

Jing Lai

Xiao-He Li

Zhi-Liang Gao

Pei-Jia Chen

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of this study was to clarify the relationships between patients who had fatal liver failure during the course of chronic hepatitis B and those who were also superinfected with hepatitis A, C, D, or E virus, as well as their hepatitis B virus e system status, so that suitable measures could be adopted to decrease the mortality of patients with chronic hepatitis B.

Methods: This study detected superinfections of hepatitis A, C, D, or E virus and the hepatitis B virus e system status in cases of fatal liver failure during the course of chronic hepatitis B by enzyme-lined immunosorbent assay.

Results: The frequency of superinfections of hepatitis A, C, D, and E virus was 1.4% (4/282), 6.4% (18/282), 1.8% (5/282), and 28.4% (80/282), respectively, overall, 37.9% (107/282). Hepatitis E was prominent and steady in superinfection rates during the past 12 years. In 62.1% (175/282) of patients, the causes of fatal liver failure were not clear. The serological status frequency of HBeAg(+) and anti-HBe(-), HBeAg(-) and anti-HBe(-), and HBeAg(-) and anti-HBe(+) was 20.6% (22/107), 23.4% (25/107), and 56.1% (60/107), respectively, in the group with superinfections of hepatitis A, C, D, or E virus and 31.4% (55/175), 21.1% (37/175), and 47.4% (83/175), respectively, in the group in which causes were not clear. The serological status HBeAg(+) and anti-HBe(-) was more frequent in the group in which causes were not clear than in the group with superinfections of hepatitis A, C, D, or E virus (P < 0.05). Statistically, there were no differences (P > 0.05) between the serological status HBeAg(-), anti-HBe(-) and HBeAg(-), anti-HBe(+) between the two groups.

Conclusions: These results suggest that superinfection (107/282) is an important factor in fatal liver failure. The mortality of chronic hepatitis B can be decreased by strict food sanitation and the use of safe blood products. There were no significant relationships between hepatitis B e antigen seroconversion and fatal liver failure during the course of chronic hepatitis B.

Citing Articles

Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure.

Fantilli A, Lopez Villa S, Zerega A, Di Cola G, Lopez L, Wassaf Martinez M Virol J. 2021; 18(1):245.

PMID: 34886883 PMC: 8662871. DOI: 10.1186/s12985-021-01714-w.

Viral Hepatitis E and Chronicity: A Growing Public Health Concern.

Thakur V, Ratho R, Kumar S, Saxena S, Bora I, Thakur P Front Microbiol. 2020; 11:577339.

PMID: 33133046 PMC: 7550462. DOI: 10.3389/fmicb.2020.577339.

Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology.

Wang Y, Liu H, Jiang Y, Pan Q, Zhao J Open Forum Infect Dis. 2020; 7(4):ofaa107.

PMID: 32355864 PMC: 7186119. DOI: 10.1093/ofid/ofaa107.

Artificial neural network-based models used for predicting 28- and 90-day mortality of patients with hepatitis B-associated acute-on-chronic liver failure.

Hou Y, Zhang Q, Gao F, Mao D, Li J, Gong Z BMC Gastroenterol. 2020; 20(1):75.

PMID: 32188419 PMC: 7081680. DOI: 10.1186/s12876-020-01191-5.

Role of Hepatitis E Virus Infection in Acute-on-Chronic Liver Failure.

Frias M, Lopez-Lopez P, Rivero A, Rivero-Juarez A Biomed Res Int. 2018; 2018:9098535.

PMID: 30050945 PMC: 6046156. DOI: 10.1155/2018/9098535.

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