Nitrite, a Naturally Occurring Precursor of Nitric Oxide That Acts Like a 'prodrug'

Overview

Journal Biol Chem

Specialty Biochemistry

Date 2006 Jun 3

PMID 16740120

Citations 17

Authors

Christoph V Suschek

Tankred Schewe

Helmut Sies

Klaus-Dietrich Kroncke

Affiliations

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Abstract

There are enzymatic and non-enzymatic mechanisms that generate NO* from nitrite in blood, stomach, saliva, urine and skin. In blood vessels, nitrite-derived NO* can provide protection via compensatory vasodilation during hypoxia, and in various body fluids it may have antibacterial activity. In the skin, nitrite-derived NO* may contribute to skin tanning, as well as to protection against UV-induced cell damage. Current knowledge on nitrite acting like an NO* 'prodrug' is presented, emphasizing the role of nitrite in skin.

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