Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-guided Near-infrared Spectral Tomography

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2006 May 30

PMID 16731633

Citations 100

Authors

Ben Brooksby

Brian W Pogue

Shudong Jiang

Hamid Dehghani

Subhadra Srinivasan

Christine Kogel

Tor D Tosteson

John Weaver

Steven P Poplack

Keith D Paulsen

Affiliations

Soon will be listed here.

Abstract

Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

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References

Pogue B, Jiang S, Dehghani H, Kogel C, Soho S, Srinivasan S . Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. J Biomed Opt. 2004; 9(3):541-52. DOI: 10.1117/1.1691028. View

Hasan J, Byers R, Jayson G . Intra-tumoural microvessel density in human solid tumours. Br J Cancer. 2002; 86(10):1566-77. PMC: 2746601. DOI: 10.1038/sj.bjc.6600315. View

Srinivasan S, Pogue B, Jiang S, Dehghani H, Kogel C, Soho S . Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography. Proc Natl Acad Sci U S A. 2003; 100(21):12349-54. PMC: 218761. DOI: 10.1073/pnas.2032822100. View

Vaupel P, Harrison L . Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist. 2004; 9 Suppl 5:4-9. DOI: 10.1634/theoncologist.9-90005-4. View

Brooksby B, Jiang S, Dehghani H, Pogue B, Paulsen K, Weaver J . Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure. J Biomed Opt. 2005; 10(5):051504. DOI: 10.1117/1.2098627. View

Brooksby B, Srinivasan S, Jiang S, Dehghani H, Pogue B, Paulsen K . Spectral priors improve near-infrared diffuse tomography more than spatial priors. Opt Lett. 2005; 30(15):1968-70. DOI: 10.1364/ol.30.001968. View

Xu Y, Zhao Y, Xu Z, Ren Y, Liu Y, Zhang Y . [Novel infrared spectroscopy methods for clinical diagnosis of tumor]. Guang Pu Xue Yu Guang Pu Fen Xi. 2006; 25(11):1775-8. View

Boyd N, Lockwood G, Byng J, Tritchler D, Yaffe M . Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 1998; 7(12):1133-44. View

Simick M, Jong R, Wilson B, Lilge L . Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk. J Biomed Opt. 2004; 9(4):794-803. DOI: 10.1117/1.1758269. View

10.

Pogue B . Near-infrared characterization of disease via vascular permeability probes. Acad Radiol. 2006; 13(1):1-3. DOI: 10.1016/j.acra.2005.11.002. View

11.

van Staveren H, Moes C, van Marie J, Prahl S, van Gemert M . Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. Appl Opt. 2010; 30(31):4507-14. DOI: 10.1364/AO.30.004507. View

12.

Haka A, Shafer-Peltier K, Fitzmaurice M, Crowe J, Dasari R, Feld M . Identifying microcalcifications in benign and malignant breast lesions by probing differences in their chemical composition using Raman spectroscopy. Cancer Res. 2002; 62(18):5375-80. View

13.

Paulsen K, Jiang H . Enhanced frequency-domain optical image reconstruction in tissues through total-variation minimization. Appl Opt. 2010; 35(19):3447-58. DOI: 10.1364/AO.35.003447. View

14.

Pifferi A, Swartling J, Chikoidze E, Torricelli A, Taroni P, Bassi A . Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances. J Biomed Opt. 2004; 9(6):1143-51. DOI: 10.1117/1.1802171. View

15.

Lenkinski R, Ahmed M, Zaheer A, Frangioni J, Goldberg S . Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer. Acad Radiol. 2003; 10(10):1159-64. DOI: 10.1016/s1076-6332(03)00253-8. View

16.

Srinivasan S, Pogue B, Brooksby B, Jiang S, Dehghani H, Kogel C . Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstruction. Technol Cancer Res Treat. 2005; 4(5):513-26. DOI: 10.1177/153303460500400505. View

17.

Kim S, Lim Y, Soltesz E, De Grand A, Lee J, Nakayama A . Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol. 2003; 22(1):93-7. PMC: 2346610. DOI: 10.1038/nbt920. View

18.

Cerussi A, Berger A, Bevilacqua F, Shah N, Jakubowski D, Butler J . Sources of absorption and scattering contrast for near-infrared optical mammography. Acad Radiol. 2001; 8(3):211-8. DOI: 10.1016/S1076-6332(03)80529-9. View

19.

Borsic A, Lionheart W, McLeod C . Generation of anisotropic-smoothness regularization filters for EIT. IEEE Trans Med Imaging. 2002; 21(6):579-87. DOI: 10.1109/TMI.2002.800611. View

20.

JOBSIS F . Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science. 1977; 198(4323):1264-7. DOI: 10.1126/science.929199. View