Focus on Molecules: Bestrophin (best-1)

Overview

Journal Exp Eye Res

Specialty Ophthalmology

Date 2006 May 25

PMID 16720022

Citations 24

Authors

Alan D Marmorstein

Tyson R Kinnick

Affiliations

Soon will be listed here.

Citing Articles

Differential Proximity of Perisynaptic Astrocytic Best1 at the Excitatory and Inhibitory Tripartite Synapses in APP/PS1 and MAOB-KO Mice Revealed by Lattice Structured Illumination Microscopy.

An H, Koh W, Kang S, Nam M, Lee C Exp Neurobiol. 2021; 30(3):213-221.

PMID: 34132201 PMC: 8278139. DOI: 10.5607/en21015.

Clinical Heterogeneity in Autosomal Recessive Bestrophinopathy with Biallelic Mutations in the Gene.

Hufendiek K, Hufendiek K, Jagle H, Stohr H, Book M, Spital G Int J Mol Sci. 2020; 21(24).

PMID: 33302512 PMC: 7763028. DOI: 10.3390/ijms21249353.

Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by computational structural biology.

Frecer V, Iarossi G, Salvetti A, Maltese P, Delledonne G, Oldani M J Transl Med. 2019; 17(1):330.

PMID: 31570112 PMC: 6771118. DOI: 10.1186/s12967-019-2080-3.

Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.

Samuel W, Jaworski C, Postnikova O, Kutty R, Duncan T, Tan L Mol Vis. 2017; 23:60-89.

PMID: 28356702 PMC: 5360456.

Unilateral BEST1-Associated Retinopathy.

Arora R, Khan K, Kasilian M, Strauss R, Holder G, Robson A Am J Ophthalmol. 2016; 169:24-32.

PMID: 27287821 PMC: 5016077. DOI: 10.1016/j.ajo.2016.05.024.

References

Sun H, Tsunenari T, Yau K, Nathans J . The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci U S A. 2002; 99(6):4008-13. PMC: 122639. DOI: 10.1073/pnas.052692999. View

Marmorstein L, Wu J, McLaughlin P, Yocom J, Karl M, Neussert R . The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1). J Gen Physiol. 2006; 127(5):577-89. PMC: 2151522. DOI: 10.1085/jgp.200509473. View

Rosenthal R, Bakall B, Kinnick T, Peachey N, Wimmers S, Wadelius C . Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells. FASEB J. 2005; 20(1):178-80. DOI: 10.1096/fj.05-4495fje. View

Hartzell C, Putzier I, Arreola J . Calcium-activated chloride channels. Annu Rev Physiol. 2005; 67:719-58. DOI: 10.1146/annurev.physiol.67.032003.154341. View