Functional Oesophago-gastric Junction Imaging
Overview
Affiliations
Despite its role in disease there is still no definitive method to assess oesophago-gastric junction competence (OGJ). Traditionally the OGJ has been assessed using manometry with lower oesophageal sphincter pressure as the indicator. More recently this has been shown not to be a very reliable marker of sphincter function and competence against reflux. Disorders such as gastro-oesophageal reflux disease and to a lesser extend achalasia still effects a significant number of patients. This review looks at using a new technique known as impedance planimetry to profile the geometry and pressure in the OGJ during distension of a bag. The data gathered can be reconstructed into a dynamic representation of OGJ action. This has been shown to provide a useful representation of the OGJ and to show changes to the competence of the OGJ in terms of compliance and distensibility as a result of endoluminal therapy.
What Is the Future of Impedance Planimetry in Gastroenterology?.
Gregersen H, Lo K J Neurogastroenterol Motil. 2018; 24(2):166-181.
PMID: 29605974 PMC: 5885717. DOI: 10.5056/jnm18013.
Ata-Lawenko R, Lee Y J Neurogastroenterol Motil. 2016; 23(2):164-170.
PMID: 28013295 PMC: 5383111. DOI: 10.5056/jnm16171.
Microdissection of Human Esophagogastric Junction Wall with Phase-contrast X-ray CT Imaging.
Zhang J, Zhou G, Tian D, Lin R, Peng G, Su M Sci Rep. 2015; 5:13831.
PMID: 26346099 PMC: 4561904. DOI: 10.1038/srep13831.
Functional lumen imaging of the gastrointestinal tract.
Lottrup C, Gregersen H, Liao D, Fynne L, Frokjaer J, Krogh K J Gastroenterol. 2015; 50(10):1005-16.
PMID: 25980822 DOI: 10.1007/s00535-015-1087-7.
Clinical potential of naloxegol in the management of opioid-induced bowel dysfunction.
Poulsen J, Brock C, Olesen A, Nilsson M, Drewes A Clin Exp Gastroenterol. 2014; 7:345-58.
PMID: 25278772 PMC: 4179399. DOI: 10.2147/CEG.S52097.