Adenovirus Type 5 E1A Gene Products Act As Transformation Suppressors of the Neu Oncogene

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1991 Mar 1

PMID 1671710

Citations 13

Authors

D H Yu

K Scorsone

M C Hung

Affiliations

Soon will be listed here.

Abstract

The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.

Citing Articles

Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene.

Loewenstein P, Green M Genes Cancer. 2011; 2(7):737-44.

PMID: 22207899 PMC: 3218411. DOI: 10.1177/1947601911426570.

Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.

Yamaguchi H, Chen C, Chou C, Pal A, Bornmann W, Hortobagyi G Oncogene. 2010; 29(41):5619-29.

PMID: 20676141 PMC: 2955174. DOI: 10.1038/onc.2010.295.

Downregulation of microRNA miR-520h by E1A contributes to anticancer activity.

Su J, Chen P, Chen Y, Chen S, Chang Y, Jan Y Cancer Res. 2010; 70(12):5096-108.

PMID: 20501832 PMC: 2891368. DOI: 10.1158/0008-5472.CAN-09-4148.

NF-kappaB in pancreatic cancer.

Sclabas G, Fujioka S, Schmidt C, Evans D, Chiao P Int J Gastrointest Cancer. 2003; 33(1):15-26.

PMID: 12909735 DOI: 10.1385/IJGC:33:1:15.

Transcriptional regulation of type I receptor tyrosine kinases in the mammary gland.

Bates N, Hurst H J Mammary Gland Biol Neoplasia. 1997; 2(2):153-63.

PMID: 10882301 DOI: 10.1023/a:1026303814855.

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