Association Study Between Kynurenine 3-monooxygenase Gene and Schizophrenia in the Japanese Population

Overview

Journal Genes Brain Behav

Specialties Genetics
Neurology
Social Sciences

Date 2006 May 24

PMID 16716206

Citations 26

Authors

N Aoyama

N Takahashi

S Saito

N Maeno

R Ishihara

X Ji

H Miura

M Ikeda

T Suzuki

T Kitajima

Y Yamanouchi

Y Kinoshita

K Yoshida

N Iwata

T Inada

N Ozaki

Affiliations

Soon will be listed here.

Abstract

Several lines of evidence suggest that metabolic changes in the kynurenic acid (KYNA) pathway are related to the etiology of schizophrenia. The inhibitor of kynurenine 3-monooxygenase (KMO) is known to increase KYNA levels, and the KMO gene is located in the chromosome region associated with schizophrenia, 1q42-q44. Single-marker and haplotype analyses for 6-tag single nucleotide polymorphisms (SNPs) of KMO were performed (cases = 465, controls = 440). Significant association of rs2275163 with schizophrenia was observed by single-marker comparisons (P = 0.032) and haplotype analysis including this SNP (P = 0.0049). Significant association of rs2275163 and haplotype was not replicated using a second, independent set of samples (cases = 480, controls = 448) (P = 0.706 and P = 0.689, respectively). These results suggest that the KMO is unlikely to be related to the development of schizophrenia in Japanese.

Citing Articles

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Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia.

Antenucci N, DErrico G, Fazio F, Nicoletti F, Bruno V, Battaglia G Schizophrenia (Heidelb). 2024; 10(1):27.

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Orsatti L, Stiehl T, Dischinger K, Speziale R, Di Pasquale P, Monteagudo E Cell Rep Med. 2021; 2(10):100409.

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Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications.

Mithaiwala M, Santana-Coelho D, Porter G, OConnor J Cells. 2021; 10(6).

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The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia.

Ulivieri M, Wieronska J, Lionetto L, Martinello K, Cieslik P, Chocyk A Schizophr Bull. 2020; 46(6):1471-1481.

PMID: 32506121 PMC: 7846105. DOI: 10.1093/schbul/sbaa074.