Microtubule-targeting Agents in Angiogenesis: Where Do We Stand?

Overview

Journal Drug Resist Updat

Specialties Infectious Diseases
Oncology

Date 2006 May 23

PMID 16714139

Citations 28

Authors

Eddy Pasquier

Stephane Honore

Diane Braguer

Affiliations

Soon will be listed here.

Abstract

Angiogenesis is a key event of tumor progression and metastasis and hence a target for cancer chemotherapy. Therapeutic strategies focused on angiogenesis include the discovery of new, targeted anti-angiogenic agents and the re-evaluation of conventional anti-cancer drugs. Here, we review the most recent studies investigating the molecular and cellular mechanisms responsible for the anti-angiogenic activity of microtubule-targeting agents (MTAs). These agents include some of the most widely used and effective antitumor drugs that are also among the most anti-angiogenic. In addition, we summarize the latest results of pre-clinical and clinical studies involving MTAs administered at low metronomic doses and in anti-angiogenic combination strategies. Finally, we discuss the future development of these agents, their clinical potential and their limitations.

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