Aquaporin-5 Water Channel in Lipid Rafts of Rat Parotid Glands

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2006 May 23

PMID 16712780

Citations 22

Authors

Yasuko Ishikawa

Gota Cho

Zhenfang Yuan

Noriko Inoue

Yoshiko Nakae

Affiliations

Soon will be listed here.

Abstract

Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion. The activation of M3 muscarinic acetylcholine receptors (mAChRs) or alpha1-adrenoceptors on the salivary glands induces salivary fluid secretion. AQP5 localizes in lipid rafts and activation of the M3 mAChRs or alpha1-adrenoceptors induced its translocation together with the lipid rafts to the APM in the interlobular ducts of rat parotid glands. This review focuses on the mechanisms of AQP5 translocation together with lipid rafts to the APM in the interlobular duct cells of parotid glands of normal rats and the impairment of AQP5 translocation in diabetes and senescence.

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