Prognostic Significance of Cyclooxygenase-2 (COX-2) Expression in Patients with Surgically Resectable Adenocarcinoma of the Oesophagus

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2006 May 23

PMID 16712734

Citations 14

Authors

Pradeep Bhandari

Adrian C Bateman

Raj L Mehta

Bernard Sf Stacey

Penny Johnson

Ian A Cree

Federica Di Nicolantonio

Praful Patel

Affiliations

Soon will be listed here.

Abstract

Background: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus.

Methods: We reviewed the records of 100 consecutive patients undergoing resection for adenocarcinoma of the oesophagus to collect data on T-stage, N-stage, tumour recurrence and survival. T & N-stage was further confirmed by histological examination. COX-2 protein expression was assessed by immunohistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients.

Results: Higher levels of COX-2 expression were associated with higher T stage (p = 0.008), higher N stage (p = 0.049), increased risk of tumour recurrence (p = 0.01) and poor survival (p = <0.001). A COX-2 score of >200 was associated with a median survival of 10 months compared to 26 months with a score of <200 (p = <0.001).

Conclusion: Higher levels of COX-2 expression are associated with poor clinico-pathologic features and poor survival in patients with oesophageal adenocarcinoma.

Citing Articles

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Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2).

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A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas.

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The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis.

Hu Z, Yang Y, Zhao Y, Huang Y Onco Targets Ther. 2017; 10:2893-2901.

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Prediagnosis aspirin use and outcomes in a prospective cohort of esophageal cancer patients.

Araujo J, Altorki N, Sonett J, Rodriguez A, Sungur-Stasik K, Spinelli C Therap Adv Gastroenterol. 2016; 9(6):806-814.

PMID: 27803735 PMC: 5076766. DOI: 10.1177/1756283X16657985.

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