Deposition Diseases and 3D Domain Swapping

Overview

Journal Structure

Publisher Cell Press

Specialties Biochemistry
Biotechnology
Cell Biology
Molecular Biology

Date 2006 May 16

PMID 16698543

Citations 96

Authors

Melanie J Bennett

Michael R Sawaya

David Eisenberg

Affiliations

Soon will be listed here.

Abstract

Protein aggregation is a feature of both normal cellular assemblies and pathological protein depositions. Although the limited order of aggregates has often impeded their structural characterization, 3D domain swapping has been implicated in the formation of several protein aggregates. Here, we review known structures displaying 3D domain swapping in the context of amyloid and related fibrils, prion proteins, and macroscopic aggregates, and we discuss the possible involvement of domain swapping in protein deposition diseases.

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