Immunological Sequelae of Trichinella Spiralis Infection in Mice: Effect on the Antibody Responses to Sheep Erythrocytes and Japanse B Encephalitis Virus

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1975 Jun 1

PMID 166916

Citations 5

Authors

A S Lubiniecki

R H Cypess

Affiliations

Soon will be listed here.

Abstract

Immunosuppression of the antibody response to Japanese B encephalitis (JBE) virus and sheep erythrocytes (SRBC) was observed in mice infected with Trichinella spiralis. This suppression was paralleled by the presence of fewer antibody-forming cells to SRBC in the spleens of parasitized mice. Both primary and secondary complement-fixing antibody responses to JBE virus were suppressed, but the development of immunological memory was not affected. Parasitized mice demonstrated a normal blastogenic response to phytohemagglutinin and normal serum clearance rate of injected (125)I-labeled immunoglobulin G(2b), although the size of the extravascular fluid compartment was significantly increased. The data presented here and in previous reports suggest that sequential antigenic competition is a possible explanation for the humoral immunosuppression to heterologous antigens caused by T. spiralis infection.

Citing Articles

Concurrent infections of Trichinella spiralis and Toxoplasma gondii in mice.

Yusuf J, PIEKARSKI G, Pelster B Z Parasitenkd. 1980; 62(3):231-40.

PMID: 7415416 DOI: 10.1007/BF00926564.

Depression of the immune response to sheep erythrocytes in mice infected with Taenia crassiceps larvae.

Good A, Miller K Infect Immun. 1976; 14(2):449-56.

PMID: 786885 PMC: 420905. DOI: 10.1128/iai.14.2.449-456.1976.

Depression of the plaque-forming cells to sheep red blood cells by the new-born larvae of Trichinella spiralis.

Faubert G Immunology. 1976; 30(4):485-9.

PMID: 773811 PMC: 1445018.

Lymphocyte activation induced by Trichinella spiralis infection reflected as spontaneous DNA synthesis in vitro.

Ljungstrom I, Sundqvist K Clin Exp Immunol. 1979; 38(2):381-8.

PMID: 230926 PMC: 1537870.

Effect of chronic Trypanosoma brucei infection on the course of louping ill virus infection in mice.

Reid H, Buxton D, Finlayson J, Holmes P Infect Immun. 1979; 23(2):192-6.

PMID: 217825 PMC: 414147. DOI: 10.1128/iai.23.2.192-196.1979.

References

Bellanti J, RUSS S, HOLMES G, Buescher E . THE NATURE OF ANTIBODIES FOLLOWING EXPERIMENTAL ARBOVIRUS INFECTION IN GUINEA PIGS. J Immunol. 1965; 94:1-11. View

Schrader J, Feldmann M . The mechanism of antigenic competition. I. The macrophage as a site of a reversible block of T-B lymphocyte collaboration. Eur J Immunol. 1973; 3(11):711-7. DOI: 10.1002/eji.1830031112. View

GERSHON R, Kondo K . Antigenic competition between heterologous erythrocytes. I. Thymic dependency. J Immunol. 1971; 106(6):1524-31. View

Cypess R, Lubiniecki A, HAMMON W . Immunosuppression and increased susceptibility to Japaneses B encephalitis virus in Trichinella spiralis-infected mice. Proc Soc Exp Biol Med. 1973; 143(2):469-73. DOI: 10.3181/00379727-143-37345. View

Lubiniecki A, Cypess R, HAMMON W . Passive immunity for arbovirus infection. II. Quantitative aspects of naturally and artificially acquired protection in mice for Japanese (B) encephalitis virus. Am J Trop Med Hyg. 1973; 22(4):535-42. DOI: 10.4269/ajtmh.1973.22.535. View

Lubiniecki A, Cypess R, Lucas J . Synergistic interaction of two agents in mice: Japanese B encephalitis virus and Trichinella spiralis. Am J Trop Med Hyg. 1974; 23(2):235-41. DOI: 10.4269/ajtmh.1974.23.235. View

Lubiniecki A, Cypess R, Lucas J . Immune response to and distribution of sheep erythrocytes in Trichinella spiralis infected mice. Tropenmed Parasitol. 1974; 25(3):345-9. View

Taussig M . Antigenic competition. Curr Top Microbiol Immunol. 1973; 60:125-74. DOI: 10.1007/978-3-642-65502-9_4. View

Pross H, Eidinger D . Antigenic competition: a review of nonspecific antigen-induced suppression. Adv Immunol. 1974; 18:133-68. DOI: 10.1016/s0065-2776(08)60309-0. View

10.

Molinari J, Cypess R, Ebersole J . Effect of Trichinella spiralis infection on the cell-mediated immune response to BCG. Int Arch Allergy Appl Immunol. 1974; 47(4):483-7. DOI: 10.1159/000231242. View

11.

Cypess R, Swidwa D, Kenny J, Yee R . Influence of a metazoan infection in the mouse on enteric colonization and immune response to Escherichia coli. J Infect Dis. 1974; 130(5):534-8. DOI: 10.1093/infdis/130.5.534. View

12.

Vathanophas K, HAMMON W, ATCHISON R, SATHER G . Attempted type specific diagnosis of dengue virus infection by the indirect fluorescent antibody method directed at differentiating IgM and IgG responses. Proc Soc Exp Biol Med. 1973; 142(2):697-702. DOI: 10.3181/00379727-142-37097. View

13.

Cypess R, Molinari J, Ebersole J, Lubiniecki A . Immunological sequelae of Trichinella spiralis infection in mice. II. Potentiation of cell-mediated response to BCG after infection with Trichinella spiralis. Infect Immun. 1974; 10(1):107-10. PMC: 414964. DOI: 10.1128/iai.10.1.107-110.1974. View

14.

Svet-Moldavsky G, Shaghijan G, Chernyakhovskaya I, Mkheidze D, Litovchenko T, Ozeretskovskaya N . Inhibition of skin allograft rejection in trichinella-infected mice. Transplantation. 1970; 9(1):69-71. DOI: 10.1097/00007890-197001000-00020. View

15.

Faubert G, Tanner C . Trichinella spiralis: inhibition of sheep hemagglutinins in mice. Exp Parasitol. 1971; 30(1):120-3. DOI: 10.1016/0014-4894(71)90077-4. View

16.

WEATHERLY N . Increased survival of Swiss mice given sublethal infections of Trichinella spiralis. J Parasitol. 1970; 56(4):748-52. View

17.

Sabet T, Newlin C, Friedman H . Effects of RES "blockade" on antibody-formation. I. Suppressed cellular and humoral haemolysin responses in mice injected with carbon particles. Immunology. 1969; 16(4):433-46. PMC: 1409641. View