[Acute Generalized Exanthematous Pustulosis with Confirmed Type IV Allergy. Report of 3 Cases]

Overview

Journal Hautarzt

Specialty Dermatology

Date 2006 May 13

PMID 16691372

Authors

K Gensch

N Hodzic-Avdagic

M Megahed

T Ruzicka

A Kuhn

Affiliations

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Abstract

Acute generalized exanthematous pustulosis (AGEP) is characterized by an acute disseminated eruption of multiple, non-follicular pustules. In addition, it can be associated with fever, elevated erythrocyte sedimentation rate, and leukocytosis. The pathogenesis of AGEP is still unknown; however, medications appear a likely cause in most cases. We report on 3 patients with AGEP demonstrating characteristic clinical and histologic features after taking amoxicillin, ampicillin, or diltiazem. All patients had positive patch test reactions to the suspected drugs.

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