Actin in Transcription and Transcription Regulation

Recent research has provided convincing evidence that actin plays several important roles in gene transcription. First, actin can bind transcription factors and determine their subcellular localization. Second, actin is a component of chromatin remodeling complexes involved in transcriptional activation. Third, actin binds directly to the RNA polymerases I, II and III, and is required for their full transcriptional activity. Fourth, actin associates with nascent mRNPs and participates in the recruitment of histone modifiers to transcribed genes. We do not know yet whether these functions are general, or restricted to certain subsets of genes.