From Cardiac Cation Channels to the Molecular Dissection of the Transient Receptor Potential Channel TRPM4

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2006 May 9

PMID 16680483

Citations 17

Authors

Bernd Nilius

Rudi Vennekens

Affiliations

Soon will be listed here.

Abstract

In 2006, we celebrate not only the milestone paper on the patch-clamp technique but also the publication of the first single-channel measurements in cardiac cells revealing a Ca(2+)-activated, nonselective cation channel. Considerable effort has been undertaken since this time to identify molecular candidates for this class of cation channels that can be found in a variety of tissues. Recent work has shown that this channel is very likely TRPM4, a member of the TRPM ion channel family. The current review links the epochal Colquhoun et al. paper to the detailed molecular knowledge and structure function aspects of this TRP channel. It will be shown that TRPM4 is a Ca(2+)- and voltage-activated channel, which is dramatically modulated by the phospholipid phosphatidyl inositol bisphosphate (PIP(2)) and belongs to the heat-activated thermoTRPs. A functional hallmark of TRPM4, as for several TRP channels, is a dramatic shift of its voltage dependence towards negative, physiologically meaningful potentials.

Citing Articles

Physiological temperature drives TRPM4 ligand recognition and gating.

Hu J, Park S, Walter T, Orozco I, ODea G, Ye X Nature. 2024; 630(8016):509-515.

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Roles of TRPM channels in glioma.

Chen Z, Xie H, Liu J, Zhao J, Huang R, Xiang Y Cancer Biol Ther. 2024; 25(1):2338955.

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Uncoupling cytosolic calcium from membrane voltage by transient receptor potential melastatin 4 channel (TRPM4) modulation: A novel strategy to treat ventricular arrhythmias.

Chakraborty P, Azam M, Masse S, Lai P, Rose R, Ibarra Moreno C Heart Rhythm O2. 2023; 4(11):725-732.

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Development and characterization of a monoclonal antibody blocking human TRPM4 channel.

Low S, Gao Y, Wei S, Chen B, Nilius B, Liao P Sci Rep. 2021; 11(1):10411.

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Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients.

Feng J, Zong P, Yan J, Yue Z, Li X, Smith C Pflugers Arch. 2021; 473(3):521-531.

PMID: 33594499 PMC: 8857941. DOI: 10.1007/s00424-021-02525-2.

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