Modulation of the Human Hair Follicle Pigmentary Unit by Corticotropin-releasing Hormone and Urocortin Peptides

Overview

Journal FASEB J

Specialties Biology
Physiology

Date 2006 May 6

PMID 16675846

Citations 23

Authors

Sobia Kauser

Andrzej Slominski

Edward T Wei

Desmond J Tobin

Affiliations

Soon will be listed here.

Abstract

Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction of cAMP with up-regulation of pro-opiomelanocortin gene expression and subsequent production of adrenocorticotropin hormone. However, the role of CRH/CRH-R in melanocyte biology is complicated by the significant heterogeneity of cutaneous melanocyte subpopulations, from continuously active and UV-responsive melanocytes in epidermis to UV nonresponsive, hair growth cycle-coupled melanogenesis in hair follicles. In the present study we report that normal human scalp hair follicle melanocytes express CRH at the mRNA level. Furthermore, CRH, urocortin and CRH-R 1 and 2 were differentially expressed in follicular melanocytes, fibroblasts, and keratinocytes depending on anatomic location and differentiation status in situ and in vitro. Stimulation of follicular melanocytes with CRH and CRH peptides, modified for selectivity for CRH-R1 and/or CRH-R2, variably induced cell melanogenesis, dendricity, and proliferation. CRH-peptides also stimulated the expression and activity of Tyrosinase, and expression of Tyrosinase-related protein-1 and-2. However, a modified urocortin peptide highly selective for CRH-R2 down-regulated melanocyte differentiation phenotype. This study indicates that CRH peptides can differentially influence hair follicle melanocyte behavior not only via CRH-R1 signaling but also by complex cross-talk between CRH-R1 and CRH-R2.

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References

Slominski A, Ermak G, Hwang J, Chakraborty A, Mazurkiewicz J, Mihm M . Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin. FEBS Lett. 1995; 374(1):113-6. DOI: 10.1016/0014-5793(95)01090-2. View

Slominski A, Paus R . Melanogenesis is coupled to murine anagen: toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol. 1993; 101(1 Suppl):90S-97S. DOI: 10.1111/1523-1747.ep12362991. View

Quevedo M, Slominski A, Pinto W, Wei E, Wortsman J . Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes. In Vitro Cell Dev Biol Anim. 2001; 37(1):50-4. DOI: 10.1290/1071-2690(2001)037<0050:peocrh>2.0.co;2. View

Slominski A, Ermak G, Mazurkiewicz J, Baker J, Wortsman J . Characterization of corticotropin-releasing hormone (CRH) in human skin. J Clin Endocrinol Metab. 1998; 83(3):1020-4. DOI: 10.1210/jcem.83.3.4650. View

Castrol M, Tomasec P, Morrison E, Murray C, Hodge P, Blanning P . Mitogenic effects and nuclear localisation of procorticotrophin-releasing hormone expressed within stably transfected fibroblast cells (CHO-K1). Mol Cell Endocrinol. 1995; 107(1):17-27. DOI: 10.1016/0303-7207(94)03416-q. View

Tobin D, Bystryn J . Different populations of melanocytes are present in hair follicles and epidermis. Pigment Cell Res. 1996; 9(6):304-10. DOI: 10.1111/j.1600-0749.1996.tb00122.x. View

Saphier P, Faria M, Grossman A, Coy D, Besser G, Hodson B . A comparison of the clearance of ovine and human corticotrophin-releasing hormone (CRH) in man and sheep: a possible role for CRH-binding protein. J Endocrinol. 1992; 133(3):487-95. DOI: 10.1677/joe.0.1330487. View

Gillbro J, Marles L, Hibberts N, Schallreuter K . Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes. J Invest Dermatol. 2004; 123(2):346-53. DOI: 10.1111/j.0022-202X.2004.23210.x. View

Slominski A, Wortsman J . Neuroendocrinology of the skin. Endocr Rev. 2000; 21(5):457-87. DOI: 10.1210/edrv.21.5.0410. View

10.

Funasaka Y, Sato H, Chakraborty A, Ohashi A, Chrousos G, Ichihashi M . Expression of proopiomelanocortin, corticotropin-releasing hormone (CRH), and CRH receptor in melanoma cells, nevus cells, and normal human melanocytes. J Investig Dermatol Symp Proc. 1999; 4(2):105-9. DOI: 10.1038/sj.jidsp.5640192. View

11.

Slominski A . Neuroendocrine system of the skin. Dermatology. 2005; 211(3):199-208. PMC: 2790059. DOI: 10.1159/000087012. View

12.

Peters E, Tobin D, Seidah N, Schallreuter K . Pro-opiomelanocortin-related peptides, prohormone convertases 1 and 2 and the regulatory peptide 7B2 are present in melanosomes of human melanocytes. J Invest Dermatol. 2000; 114(3):430-7. DOI: 10.1046/j.1523-1747.2000.00913.x. View

13.

Slominski A, Tobin D, Shibahara S, Wortsman J . Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 2004; 84(4):1155-228. DOI: 10.1152/physrev.00044.2003. View

14.

Slominski A, Wortsman J, Luger T, Paus R, Solomon S . Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev. 2000; 80(3):979-1020. DOI: 10.1152/physrev.2000.80.3.979. View

15.

Slominski A, Wortsman J, Pisarchik A, Zbytek B, Linton E, Mazurkiewicz J . Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J. 2001; 15(10):1678-93. DOI: 10.1096/fj.00-0850rev. View

16.

Ito N, Ito T, Betterman A, Paus R . The human hair bulb is a source and target of CRH. J Invest Dermatol. 2004; 122(1):235-7. DOI: 10.1046/j.1523-1747.2003.22145.x. View

17.

Rees J . Genetics of hair and skin color. Annu Rev Genet. 2003; 37:67-90. DOI: 10.1146/annurev.genet.37.110801.143233. View

18.

Zouboulis C, Seltmann H, Hiroi N, Chen W, Young M, Oeff M . Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A. 2002; 99(10):7148-53. PMC: 124543. DOI: 10.1073/pnas.102180999. View

19.

Magerl M, Kauser S, Paus R, Tobin D . Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles. Exp Dermatol. 2002; 11(4):381-5. DOI: 10.1034/j.1600-0625.2002.110414.x. View

20.

Slominski A, Wortsman J, Plonka P, Schallreuter K, Paus R, Tobin D . Hair follicle pigmentation. J Invest Dermatol. 2005; 124(1):13-21. PMC: 1201498. DOI: 10.1111/j.0022-202X.2004.23528.x. View