Periodontitis and Plasma C-reactive Protein During Pregnancy

Overview

Journal J Periodontol

Date 2006 May 5

PMID 16671874

Citations 9

Authors

Waranuch Pitiphat

Kaumudi J Joshipura

Janet W Rich-Edwards

Paige L Williams

Chester W Douglass

Matthew W Gillman

Affiliations

Soon will be listed here.

Abstract

Background: Periodontitis has been associated with increased risk of adverse pregnancy outcomes and elevated C-reactive protein (CRP) concentrations in non-pregnant adults. We examined the relationship between periodontitis and CRP among women who provided dental radiographs and had blood collected during early pregnancy, excluding smokers and diabetic patients.

Methods: From Project Viva, an ongoing cohort study, we measured plasma CRP in 35 subjects with periodontitis (i.e., at least one site with > or =3 mm of alveolar bone loss) and a random sample of 66 periodontally healthy subjects matched on age and race/ethnicity. We performed linear regression analysis with log-transformed CRP levels as the outcome.

Results: The mean (+/- SE) CRP level was 65% higher (95% confidence interval: -2%, 180%; P = 0.06) in women with periodontitis (2.46 +/- 0.52 mg/l) than in controls (1.49 +/- 0.22 mg/l), adjusting for factors related to CRP levels, including age, race/ethnicity, pre-pregnancy body mass index, alcohol intake, education, income, and gestational age at blood collection.

Conclusions: These findings suggest that periodontitis may increase CRP levels in pregnancy. CRP could potentially mediate the association of periodontitis with adverse pregnancy outcomes.

Citing Articles

Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review.

Alsharief M, Alabdurubalnabi E Life (Basel). 2023; 13(7).

PMID: 37511934 PMC: 10381683. DOI: 10.3390/life13071559.

Effect of intra-pregnancy nonsurgical periodontal therapy on inflammatory biomarkers and adverse pregnancy outcomes: a systematic review with meta-analysis.

Silva H, Stefani C, Melo N, Lima A, Rosing C, Porporatti A Syst Rev. 2017; 6(1):197.

PMID: 29017560 PMC: 5635531. DOI: 10.1186/s13643-017-0587-3.

Estimation of changes in C-reactive protein level and pregnancy outcome after nonsurgical supportive periodontal therapy in women affected with periodontitis in a rural set up of India.

Khairnar M, Pawar B, Marawar P, Khairnar D Contemp Clin Dent. 2015; 6(Suppl 1):S5-S11.

PMID: 25821375 PMC: 4374319. DOI: 10.4103/0976-237X.152930.

Comparative evaluation of serum C-reactive protein levels in chronic and aggressive periodontitis patients and association with periodontal disease severity.

Goyal L, Bey A, Gupta N, Sharma V Contemp Clin Dent. 2014; 5(4):484-8.

PMID: 25395764 PMC: 4229757. DOI: 10.4103/0976-237X.142816.

Association between Periodontopathogens and CRP Levels in Patients with Periodontitis in Serbia.

Pejcic A, Kesic L, Milasin J J Dent Res Dent Clin Dent Prospects. 2012; 5(1):10-6.

PMID: 23019501 PMC: 3429984. DOI: 10.5681/joddd.2011.003.

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