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The Implications of a Growing Evidence Base for Drug Use in Elderly Patients. Part 4. Vitamin D and Bisphosphonates for Fractures and Osteoporosis

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Specialty Pharmacology
Date 2006 May 4
PMID 16669844
Citations 1
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Abstract

Fractures are common in elderly subjects, disabling and occasionally fatal. Their incidence increases exponentially with age, with the commonest affected sites being the wrist, vertebrae, hip and humerus. Of these, hip fractures are the most relevant in terms of morbidity and financial cost. The increase in fracture rate with age is believed to result predominantly from age-related increases in the incidence of osteoporosis and falls. This article reviews the evidence for the use of vitamin D and bisphosphonates for the prevention of bone fractures and osteoporosis in elderly patients.

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References
1.
Ringe J, Dorst A, Faber H, Ibach K . Alendronate treatment of established primary osteoporosis in men: 3-year results of a prospective, comparative, two-arm study. Rheumatol Int. 2003; 24(2):110-3. DOI: 10.1007/s00296-003-0388-y. View

2.
Dawson-Hughes B, Harris S, Krall E, Dallal G . Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997; 337(10):670-6. DOI: 10.1056/NEJM199709043371003. View

3.
McClung M, Geusens P, Miller P, Zippel H, Bensen W, Roux C . Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. N Engl J Med. 2001; 344(5):333-40. DOI: 10.1056/NEJM200102013440503. View

4.
Trivedi D, Doll R, Khaw K . Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003; 326(7387):469. PMC: 150177. DOI: 10.1136/bmj.326.7387.469. View

5.
Scharla S . Prevalence of subclinical vitamin D deficiency in different European countries. Osteoporos Int. 1999; 8 Suppl 2:S7-12. DOI: 10.1007/pl00022726. View