Cardiac Magnetic Resonance Appearance of Myocarditis Caused by High Dose IL-2: Similarities to Community-acquired Myocarditis

Overview

Journal J Cardiovasc Magn Reson

Publisher Elsevier

Specialties Cardiology & Vascular Diseases
Radiology

Date 2006 May 4

PMID 16669178

Citations 10

Authors

W Patricia Ingkanisorn

D Ian Paterson

Katherine R Calvo

Douglas R Rosing

Douglas J Schwartzentruber

Anthon R Fuisz

Andrew E Arai

Affiliations

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Abstract

The purpose of this study was to describe and compare the cardiac magnetic resonance (CMR) characteristics of myocarditis caused by high dose interleukin-2 (7 patients) with community-acquired myocarditis (14 patients). A total of 21 patients with suspected myocarditis and elevated cardiac enzymes underwent cine CMR followed by delayed enhancement. The mean ejection fraction was mildly decreased in both groups. The location, pattern, and extent of DE were similar in both groups of patients. The CMR similarities between these two populations suggest that cytokine-mediated cytotoxicity may play an important role in community-acquired myocarditis.

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