Inhibition of Ribulose 1,5-diphosphate Carboxylase by 6-phosphogluconate

Overview

Journal Plant Physiol

Specialty Physiology

Date 1972 Aug 1

PMID 16658146

Citations 14

Authors

D K Chu

J A Bassham

Affiliations

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Abstract

6-Phosphogluconate is a much more effective inhibitor of the photosynthetic carboxylation enzyme, ribulose-1, 5-diphosphate carboxylase, than other sugar phosphates and sugar acids of the reductive and oxidative pentose phosphate cycles. The inhibition appears to be noncompetitive with ribulose 1,5-diphosphate. Since 6-phosphogluconate is unique to the oxidative cycle and inhibits at concentrations comparable to those found in vivo, it is proposed that its inhibition of the carboxylase may be a regulatory factor. If so, it would operate during darkness as a different control factor from those factors postulated to activate the carboxylase during photosynthesis.

Citing Articles

Carbon metabolism of chloroplasts in the dark: Oxidative pentose phosphate cycle versus glycolytic pathway.

Kaiser W, Bassham J Planta. 2014; 144(2):193-200.

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Analysis of Chromophytic and Rhodophytic Ribulose-1,5-Bisphosphate Carboxylase Indicates Extensive Structural and Functional Similarities among Evolutionarily Diverse Algae.

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Site of action of inhibitors of carbon dioxide assimilation by whole lettuce chloroplasts.

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Transport of Metabolites across Isolated Envelope Membranes of Spinach Chloroplasts.

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Regulation of ribulose 1,5-diphosphate carboxylase by substrates and other metabolites: further evidence for several types of binding sites.

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