Pneumonitis in Human Cytomegalovirus Infection

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2006 Apr 29

PMID 16643774

Citations 1

Authors

Erik Langhoff

Robert E Siegel

Affiliations

Soon will be listed here.

Abstract

Human cytomegalovirus (HCMV) is a beta herpes virus with a double stranded DNA genome of 240kbp. The virus is prevalent and establishes a latent infection in most adults. HCMV is an opportunistic pathogen for patients with impaired cellular immunity. HCMV pneumonia is a common presentation of HCMV disease in immunocompromised patients. The incidence of HCMV pneumonitis can be as high as 90% in lung transplant recipients. This paper takes a fresh look at the challenging perspectives of molecular, immunologic, cellular, diagnostic, clinical, and therapeutic characteristics of HCMV infection as future targets for development of antiviral strategies.

Citing Articles

Effects of intrapulmonary viral tropism and cytokine expression on the histological patterns of cytomegalovirus pneumonia.

Arai Y, Tsuchida T, Kosugi I, Kawasaki H, Meguro S, Kinoshita M Pathol Int. 2012; 62(9):628-39.

PMID: 22924849 PMC: 3509368. DOI: 10.1111/j.1440-1827.2012.02849.x.

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