Serotonin 5-HT2A and 5-HT6 Receptors in the Prefrontal Cortex of Alzheimer and Normal Aging Patients

Overview

Journal BMC Neurosci

Publisher Biomed Central

Specialty Neurology

Date 2006 Apr 28

PMID 16640790

Citations 39

Authors

Dietrich E Lorke

Gang Lu

Eric Cho

David T Yew

Affiliations

Soon will be listed here.

Abstract

Background: It has been hypothesized that alterations of the serotonergic system contribute to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have therefore been determined by immunohistochemistry in the prefrontal cortex of patients with AD (n=6) and normal age-matched controls (n = 7).

Results: In normal aging patients, 5-HT2A label was mainly observed in large pyramidal cells, but to a lesser extent also in small pyramidal cells and in stellate cells of cortical layers II-VI. In AD, a similar distribution was observed, but density of positive cells was significantly reduced by 33%. In aging control patients, the 5-HT6 receptor was expressed by pyramidal cells and occasional stellate cells, not only of layers II-V, but also of layer I, where a distinct label was observed in neurons and surrounding fibers. 5-HT6 receptor expression in AD patients had the same pattern, but was significantly decreased by 40%.

Conclusion: Our results indicate that a decline in neurons expressing 5-HT2A, but also 5-HT6 receptors may play a role in the etiopathology of neuropsychiatric symptoms in AD.

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