The Frequency of Hypermobility and Its Relationship with Clinical Findings of Fibromyalgia Patients

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2006 Apr 26

PMID 16636935

Citations 14

Authors

O Faruk Sendur

Gulcan Gurer

Gulnur Tasci Bozbas

Affiliations

Soon will be listed here.

Abstract

The etiology and pathogenic mechanisms of fibromyalgia (FM) are unknown. A number of studies have suggested that there was a link between hypermobility and FM. In this study, we aimed to expose the frequency of hypermobility in FM patients and its relation with clinical findings. For this reason, 236 women (118 FM women as study group and 118 healthy women as control group) were enrolled in the study. Joint hypermobility was evaluated in the participants by using Beighton scoring system. The rate of joint hypermobility among FM patients (Beighton score of at least 4 or more) was found to be higher than the control group (46.6 vs 28.8%). This result was also statistically meaningful (p<0.05). In addition, the mean Beighton score of FM group was observed to be higher than the control (3.68 vs 2.55, p<0.001). Although not reaching statistical difference (p>0.05), more severe clinical findings were observed in FM patients with hypermobility when compared with ones without.

Citing Articles

Neuroinflammatory and Immunological Aspects of Fibromyalgia.

Findeisen K, Guymer E, Littlejohn G Brain Sci. 2025; 15(2).

PMID: 40002538 PMC: 11852494. DOI: 10.3390/brainsci15020206.

Prevalence and Contextual Factors of Juvenile Fibromyalgia in a Population-Based Italian Sample of Children and Adolescents.

Maddali Bongi S, Vitali Rosati G, Bonaccorsi G, Lorini C Biomedicines. 2023; 11(6).

PMID: 37371677 PMC: 10295732. DOI: 10.3390/biomedicines11061583.

Juvenile primary Fibromyalgia Syndrome: epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis.

Coles M, Weissmann R, Uziel Y Pediatr Rheumatol Online J. 2021; 19(1):22.

PMID: 33648522 PMC: 7923821. DOI: 10.1186/s12969-021-00493-6.

Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes.

Gensemer C, Burks R, Kautz S, Judge D, Lavallee M, Norris R Dev Dyn. 2020; 250(3):318-344.

PMID: 32629534 PMC: 7785693. DOI: 10.1002/dvdy.220.

Keeping a Flexible Differential Diagnosis: an Exercise in Clinical Reasoning.

Bergl P, Manesh R, Basel D, Olson A J Gen Intern Med. 2019; 34(6):1063-1068.

PMID: 30847831 PMC: 6544697. DOI: 10.1007/s11606-019-04867-1.

References

Gedalia A, Press J, Klein M, Buskila D . Joint hypermobility and fibromyalgia in schoolchildren. Ann Rheum Dis. 1993; 52(7):494-6. PMC: 1005086. DOI: 10.1136/ard.52.7.494. View

Wolfe F, Anderson J, HARKNESS D, Bennett R, Caro X, Goldenberg D . Health status and disease severity in fibromyalgia: results of a six-center longitudinal study. Arthritis Rheum. 1997; 40(9):1571-9. DOI: 10.1002/art.1780400905. View

Burckhardt C, Clark S, Bennett R . The fibromyalgia impact questionnaire: development and validation. J Rheumatol. 1991; 18(5):728-33. View

Wallace D . The fibromyalgia syndrome. Ann Med. 1997; 29(1):9-21. DOI: 10.3109/07853899708998739. View

Acasuso-Diaz M, Collantes-Estevez E . Joint hypermobility in patients with fibromyalgia syndrome. Arthritis Care Res. 1998; 11(1):39-42. DOI: 10.1002/art.1790110107. View

Hudson N, Starr M, Esdaile J, Fitzcharles M . Diagnostic associations with hypermobility in rheumatology patients. Br J Rheumatol. 1995; 34(12):1157-61. DOI: 10.1093/rheumatology/34.12.1157. View

PERRINI F, Tallents R, Katzberg R, Ribeiro R, Kyrkanides S, Moss M . Generalized joint laxity and temporomandibular disorders. J Orofac Pain. 1997; 11(3):215-21. View

Bridges A, Smith E, Reid J . Joint hypermobility in adults referred to rheumatology clinics. Ann Rheum Dis. 1992; 51(6):793-6. PMC: 1004749. DOI: 10.1136/ard.51.6.793. View

Grahame R . Joint hypermobility and genetic collagen disorders: are they related?. Arch Dis Child. 1999; 80(2):188-91. PMC: 1717821. DOI: 10.1136/adc.80.2.188. View

10.

Larsson L, Baum J, Mudholkar G, Kollia G . Benefits and disadvantages of joint hypermobility among musicians. N Engl J Med. 1993; 329(15):1079-82. DOI: 10.1056/NEJM199310073291504. View

11.

Kraus V, Li Y, Martin E, Jordan J, Renner J, Doherty M . Articular hypermobility is a protective factor for hand osteoarthritis. Arthritis Rheum. 2004; 50(7):2178-83. DOI: 10.1002/art.20354. View

12.

Klemp P . Hypermobility. Ann Rheum Dis. 1997; 56(10):573-5. PMC: 1752264. DOI: 10.1136/ard.56.10.573. View

13.

Sarmer S, Ergin S, Yavuzer G . The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int. 2001; 20(1):9-12. DOI: 10.1007/s002960000077. View

14.

Holman A . Is hypermobility a factor in fibromyalgia?. J Rheumatol. 2002; 29(2):396-8. View

15.

Bulbena A, Duro J, Porta M, Faus S, Vallescar R, Martin-Santos R . Clinical assessment of hypermobility of joints: assembling criteria. J Rheumatol. 1992; 19(1):115-22. View

16.

Gedalia A, BREWER Jr E . Joint hypermobility in pediatric practice--a review. J Rheumatol. 1993; 20(2):371-4. View

17.

Barron D, Cohen B, Geraghty M, Violand R, Rowe P . Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls. J Pediatr. 2002; 141(3):421-5. DOI: 10.1067/mpd.2002.127496. View

18.

Kirk J, ANSELL B, Bywaters E . The hypermobility syndrome. Musculoskeletal complaints associated with generalized joint hypermobility. Ann Rheum Dis. 1967; 26(5):419-25. PMC: 1031347. DOI: 10.1136/ard.26.5.419. View

19.

Wolfe F, Ross K, Anderson J, Russell I, Hebert L . The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995; 38(1):19-28. DOI: 10.1002/art.1780380104. View

20.

Hudson N, Fitzcharles M, Cohen M, Starr M, Esdaile J . The association of soft-tissue rheumatism and hypermobility. Br J Rheumatol. 1998; 37(4):382-6. DOI: 10.1093/rheumatology/37.4.382. View