The Developmental Behavior Genetics of Drug Involvement: Overview and Comments

Overview

Journal Behav Genet

Date 2006 Apr 26

PMID 16636903

Citations 8

Authors

Robert A Zucker

Affiliations

Soon will be listed here.

Abstract

The papers in this special issue have in common an interest in developmental variations in the heritability of substance use, abuse, and problems. A number of the studies are longitudinal, and even those that are cross-sectional are analytically focused on whether heritability, shared, and nonshared environmentality effects are constant or change over the period from onset of use to the time when problem use is more constant. This commentary provides an overview of the work from a developmental psychopathology perspective. Findings are linked to the existing longitudinal/developmental literature on the epigenesis of substance use disorders and similarities and contradictions are noted. Suggestions for next step work, involving the need for increased differentiation of the substance abuse phenotypes, the utilization of phenotypic measures that delineate heterogeneity of course, and more precise definition of the specific environmental variations that underlie shared and nonshared environmental liability, are provided.

Citing Articles

Simultaneous versus concurrent use of alcohol and cannabis in the National Alcohol Survey.

Subbaraman M, Kerr W Alcohol Clin Exp Res. 2015; 39(5):872-9.

PMID: 25872596 PMC: 4399000. DOI: 10.1111/acer.12698.

The great opportunity: Evolutionary applications to medicine and public health.

Nesse R, Stearns S Evol Appl. 2015; 1(1):28-48.

PMID: 25567489 PMC: 3352398. DOI: 10.1111/j.1752-4571.2007.00006.x.

The role of early childhood ADHD and subsequent CD in the initiation and escalation of adolescent cigarette, alcohol, and marijuana use.

Sibley M, Pelham W, Molina B, Coxe S, Kipp H, Gnagy E J Abnorm Psychol. 2014; 123(2):362-374.

PMID: 24886010 PMC: 4120046. DOI: 10.1037/a0036585.

Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence.

Ersche K, Turton A, Chamberlain S, Muller U, Bullmore E, Robbins T Am J Psychiatry. 2012; 169(9):926-36.

PMID: 22952072 PMC: 3533378. DOI: 10.1176/appi.ajp.2012.11091421.

Interaction between the DRD4 VNTR polymorphism and proximal and distal environments in alcohol dependence during emerging and young adulthood.

Park A, Sher K, Todorov A, Heath A J Abnorm Psychol. 2011; 120(3):585-95.

PMID: 21381802 PMC: 3139825. DOI: 10.1037/a0022648.

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