Cortical Modulation of Dorsal Column Nuclei: a Computational Study

Overview

Journal J Comput Neurosci

Specialties Biology
Neurology

Date 2006 Apr 25

PMID 16633940

Citations 1

Authors

Eduardo Sanchez

Senen Barro

Jorge Marino

Antonio Canedo

Affiliations

Soon will be listed here.

Abstract

We present a computational study aimed at exploring the sensorimotor cortex modulation of the behaviour of dorsal column nuclei, specifically the impact of synaptic parameters, during both sleep and waking conditions. On the basis of the circuit proposed by Canedo et al. (2000), we have developed realistic computational models that have been tested with simultaneous electrocorticographic as well as intracellular cuneate recordings performed in anaesthetized cats. The results show that, (1) under sleep conditions, the model can block the transmission of afferent sensory information and, (2) operations expected during wakefulness, such as filtering and facilitation, can be performed if synaptic parameters are appropriately tuned.

Citing Articles

Modulation of neuronal activity in dorsal column nuclei by upper cervical spinal cord stimulation in rats.

Qin C, Yang X, Wu M, Farber J, Linderoth B, Foreman R Neuroscience. 2009; 164(2):770-6.

PMID: 19665525 PMC: 2762014. DOI: 10.1016/j.neuroscience.2009.08.001.

References

Jack J, Redman S . The propagation of transient potentials in some linear cable structures. J Physiol. 1971; 215(2):283-320. PMC: 1331886. DOI: 10.1113/jphysiol.1971.sp009472. View

Huguenard J, Hamill O, Prince D . Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component. J Neurophysiol. 1988; 59(3):778-95. DOI: 10.1152/jn.1988.59.3.778. View

Levitt M, Carreras M, Liu C, CHAMBERS W . PYRAMIDAL AND EXTRAPYRAMIDAL MODULATION OF SOMATOSENSORY ACTIVITY IN GRACILE AND CUNEATE NUCLEI. Arch Ital Biol. 1964; 102:197-229. View

Andersen P, ECCLES J, Oshima T, Schmidt R . MECHANISMS OF SYNAPTIC TRANSMISSION IN THE CUNEATE NUCLEUS. J Neurophysiol. 1964; 27:1096-116. DOI: 10.1152/jn.1964.27.6.1096. View

Huguenard J, McCormick D . Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. J Neurophysiol. 1992; 68(4):1373-83. DOI: 10.1152/jn.1992.68.4.1373. View

Andersen P, ECCLES J, Schmidt R, Yokota T . DEPOLARIZATION OF PRESYNAPTIC FIBERS IN THE CUNEATE NUCLEUS. J Neurophysiol. 1964; 27:92-106. DOI: 10.1152/jn.1964.27.1.92. View

Canedo A, Marino J, Aguilar J . Lemniscal recurrent and transcortical influences on cuneate neurons. Neuroscience. 2000; 97(2):317-34. DOI: 10.1016/s0306-4522(00)00063-4. View

Marino J, Martinez L, Canedo A . Coupled slow and delta oscillations between cuneothalamic and thalamocortical neurons in the chloralose anesthetized cat. Neurosci Lett. 1996; 219(2):107-10. DOI: 10.1016/s0304-3940(96)13184-0. View

Marino J, Canedo A, Aguilar J . Sensorimotor cortical influences on cuneate nucleus rhythmic activity in the anesthetized cat. Neuroscience. 2000; 95(3):657-73. DOI: 10.1016/s0306-4522(99)00414-5. View

10.

Jabbur S, TOWE A . Cortical excitation of neurons in dorsal column nuclei of cat, including an analysis of pathways. J Neurophysiol. 1961; 24:499-509. DOI: 10.1152/jn.1961.24.5.499. View

11.

Cheema S, Fyffe R, Light A, Rustioni A . Arborizations of single corticofugal axons in the feline cuneate nucleus stained by iontophoretic injection of horseradish peroxidase. Brain Res. 1984; 290(1):158-64. DOI: 10.1016/0006-8993(84)90747-9. View

12.

Sotgiu M, Margnelli M . Electrophysiological identification of pontomedullary reticular neurons directly projecting into dorsal column nuclei. Brain Res. 1976; 103(3):443-53. DOI: 10.1016/0006-8993(76)90443-1. View

13.

TOWE A, Jabbur S . Cortical inhibition of neurons in dorsal column nuclei of cat. J Neurophysiol. 1961; 24:488-98. DOI: 10.1152/jn.1961.24.5.488. View

14.

Britten K . Cortical neurophysiology. Attention is everywhere. Nature. 1996; 382(6591):497-8. DOI: 10.1038/382497a0. View

15.

DARIAN-SMITH I, Yokota T . Corticofugal effects on different neuron types within the cat's brain stem activated by tactile stimulation of the face. J Neurophysiol. 1966; 29(2):185-206. DOI: 10.1152/jn.1966.29.2.185. View

16.

Marino J, Martinez L, Canedo A . Sensorimotor Integration at the Dorsal Column Nuclei. News Physiol Sci. 2001; 14:231-237. DOI: 10.1152/physiologyonline.1999.14.6.231. View

17.

Winter D . N. GRACILIS OF CAT. FUNCTIONAL ORGANIZATION AND CORTICOFUGAL EFFECTS. J Neurophysiol. 1965; 28:48-70. DOI: 10.1152/jn.1965.28.1.48. View

18.

Canedo A, Martinez L, Marino J . Tonic and bursting activity in the cuneate nucleus of the chloralose-anesthetized cat. Neuroscience. 1998; 84(2):603-17. DOI: 10.1016/s0306-4522(97)00554-x. View

19.

Martinez L, Lamas J, Canedo A . Pyramidal tract and corticospinal neurons with branching axons to the dorsal column nuclei of the cat. Neuroscience. 1995; 68(1):195-206. DOI: 10.1016/0306-4522(95)00133-4. View

20.

BIEDENBACH M, DEVITO J . Origin of the pyramidal tract determined with horseradish peroxidase. Brain Res. 1980; 193(1):1-17. DOI: 10.1016/0006-8993(80)90941-5. View