Wide Field Multifocal and Standard Full Field Electroretinographic Features of Hemi Retinal Vein Occlusion

Overview

Journal Doc Ophthalmol

Specialty Ophthalmology

Date 2006 Apr 25

PMID 16633725

Citations 6

Authors

Fiona Mary Dolan

Stuart Parks

David Keating

Gordon Neale Dutton

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to document the standard full field electroretinographic (ERG) and wide field multifocal electroretinographic (WF-mfERG) findings in eyes with recent onset hemi-retinal vein occlusion (HRVO) and to compare the electro-diagnostic findings in the affected and fellow eyes with reference to normative data. Eight patients with HRVO were assessed using ERG and WF-mfERG. WF-mfERG first order responses from the affected hemi-retinae and the unaffected hemi-retinae in each affected eye were compared. WF-mfERG responses from each affected hemi-retina and from the symmetrical hemi-retina of each fellow eye were compared. ERG responses between affected and unaffected eyes were also compared. All electrodiagnostic tests were compared to normative data (5-95% confidence limits derived from age-related controls). WF-mfERG P1 and N1 implicit times were greater for the affected hemi-retinae than for the unaffected hemi-retinae (p <0.05). WF-mfERG N1 and P1 implicit times were prolonged (p < 0.05) and WF-mfERG P1/N1 amplitude ratios were significantly reduced (p < 0.05) for the affected eyes when compared with the fellow eyes. Maximal b-wave, cone b-wave and flicker implicit times were prolonged (p < 0.05) when comparing affected and fellow eyes. These results indicate that retinal injury due to HRVO culminates in significant delay of both ERG and WF-mfERG implicit times. These results suggest that WF-mfERG in combination with ERG may have a role in the management of HRVO.

Citing Articles

Impact of contact lens materials on the mfERG response of the human retina.

Amorim-de-Sousa A, Moreira L, Macedo-de-Araujo R, Amorim A, Jorge J, Fernandes P Doc Ophthalmol. 2019; 140(2):103-113.

PMID: 31571070 DOI: 10.1007/s10633-019-09722-6.

Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy.

Tzekov R, Madow B J Ophthalmol. 2015; 2015:680215.

PMID: 26246903 PMC: 4515528. DOI: 10.1155/2015/680215.

Association of electroretinogram and morphological findings in central retinal vein occlusion with macular edema.

Noma H, Mimura T, Kuse M, Shimada K Clin Ophthalmol. 2014; 8:191-7.

PMID: 24531560 PMC: 3891666. DOI: 10.2147/OPTH.S54546.

Multifocal electroretinogram in retinal vein occlusion.

Abdel-Kader M, El-Dessouky W Saudi J Ophthalmol. 2013; 24(4):125-32.

PMID: 23960889 PMC: 3729305. DOI: 10.1016/j.sjopt.2010.04.005.

Interocular symmetry of abnormal multifocal electroretinograms in adolescents with diabetes and no retinopathy.

Laron M, Bearse Jr M, Bronson-Castain K, Jonasdottir S, King-Hooper B, Barez S Invest Ophthalmol Vis Sci. 2011; 53(1):316-21.

PMID: 22159016 PMC: 3292367. DOI: 10.1167/iovs.11-8825.

References

Breton M, Quinn G, Keene S, Dahmen J, Brucker A . Electroretinogram parameters at presentation as predictors of rubeosis in central retinal vein occlusion patients. Ophthalmology. 1989; 96(9):1343-52. DOI: 10.1016/s0161-6420(89)32742-4. View

Appiah A, Greenidge K . Factors associated with retinal-vein occlusion in Hispanics. Ann Ophthalmol. 1987; 19(8):307-9, 312. View

Nagatomo A, Nao-i N, Maruiwa F, Arai M, Sawada A . Multifocal electroretinograms in normal subjects. Jpn J Ophthalmol. 1998; 42(2):129-35. DOI: 10.1016/s0021-5155(97)00118-4. View

Ireland J, Keating D, Hoggar S, Parks S . Identification of appropriate primitive polynomials to avoid cross-contamination in multifocal electroretinogram responses. Med Biol Eng Comput. 2002; 40(4):471-8. DOI: 10.1007/BF02345081. View

Kretschmann U, Seeliger M, Ruether K, Usui T, Zrenner E . Spatial cone activity distribution in diseases of the posterior pole determined by multifocal electroretinography. Vision Res. 1999; 38(23):3817-28. DOI: 10.1016/s0042-6989(98)00071-6. View

Sutter E, Tran D . The field topography of ERG components in man--I. The photopic luminance response. Vision Res. 1992; 32(3):433-46. DOI: 10.1016/0042-6989(92)90235-b. View

Williamson T, Keating D, Bradnam M . Electroretinography of central retinal vein occlusion under scotopic and photopic conditions: what to measure?. Acta Ophthalmol Scand. 1997; 75(1):48-53. DOI: 10.1111/j.1600-0420.1997.tb00249.x. View

Morrell A, Thompson D, Gibson J, Kritzinger E, Drasdo N . Electroretinography as a prognostic indicator or neovascularisation in CRVO. Eye (Lond). 1991; 5 ( Pt 3):362-8. DOI: 10.1038/eye.1991.58. View

Hayreh S, Klugman M, Beri M, Kimura A, Podhajsky P . Differentiation of ischemic from non-ischemic central retinal vein occlusion during the early acute phase. Graefes Arch Clin Exp Ophthalmol. 1990; 228(3):201-17. DOI: 10.1007/BF00920022. View

10.

Larsson J, Andreasson S . Photopic 30 Hz flicker ERG as a predictor for rubeosis in central retinal vein occlusion. Br J Ophthalmol. 2001; 85(6):683-5. PMC: 1724015. DOI: 10.1136/bjo.85.6.683. View

11.

Hayreh S, Zimmerman M, Beri M, Podhajsky P . Intraocular pressure abnormalities associated with central and hemicentral retinal vein occlusion. Ophthalmology. 2004; 111(1):133-41. DOI: 10.1016/j.ophtha.2003.03.002. View

12.

Sakaue H, KATSUMI O, Hirose T . Electroretinographic findings in fellow eyes of patients with central retinal vein occlusion. Arch Ophthalmol. 1989; 107(10):1459-62. DOI: 10.1001/archopht.1989.01070020533033. View

13.

Hayreh S, Hayreh M . Hemi-central retinal vein occulsion. Pathogenesis, clinical features, and natural history. Arch Ophthalmol. 1980; 98(9):1600-9. DOI: 10.1001/archopht.1980.01020040452011. View

14.

Johnson M, MARCUS S, Elman M, McPhee T . Neovascularization in central retinal vein occlusion: electroretinographic findings. Arch Ophthalmol. 1988; 106(3):348-52. DOI: 10.1001/archopht.1988.01060130374025. View

15.

Kaye S, Harding S . Early electroretinography in unilateral central retinal vein occlusion as a predictor of rubeosis iridis. Arch Ophthalmol. 1988; 106(3):353-6. DOI: 10.1001/archopht.1988.01060130379026. View

16.

Matsui Y, KATSUMI O, Sakaue H, Hirose T . Electroretinogram b/a wave ratio improvement in central retinal vein obstruction. Br J Ophthalmol. 1994; 78(3):191-8. PMC: 504735. DOI: 10.1136/bjo.78.3.191. View

17.

Hood D . Assessing retinal function with the multifocal technique. Prog Retin Eye Res. 2000; 19(5):607-46. DOI: 10.1016/s1350-9462(00)00013-6. View

18.

Sabates R, Hirose T, McMeel J . Electroretinography in the prognosis and classification of central retinal vein occlusion. Arch Ophthalmol. 1983; 101(2):232-5. DOI: 10.1001/archopht.1983.01040010234010. View

19.

Marmor M, Zrenner E . Standard for clinical electroretinography (1999 update). International Society for Clinical Electrophysiology of Vision. Doc Ophthalmol. 2000; 97(2):143-56. DOI: 10.1023/a:1002016531591. View

20.

Marmor M, Hood D, Keating D, Kondo M, Seeliger M, Miyake Y . Guidelines for basic multifocal electroretinography (mfERG). Doc Ophthalmol. 2003; 106(2):105-15. DOI: 10.1023/a:1022591317907. View