Interactions Between Mycoplasma Lipid-associated Membrane Proteins and the Host Cells

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2006 Apr 15

PMID 16615163

Citations 19

Authors

Xiao-Xing You

Yan-Hua Zeng

Yi-Mou Wu

Affiliations

Soon will be listed here.

Abstract

Mycoplamas are a group of wall-less prokaryotes widely distributed in nature, some of which are pathogenic for humans and animals. There are many lipoproteins anchored on the outer face of the plasma membrane, called lipid-associated membrane proteins (LAMPs). LAMPs are highly antigenic and could undergo phase and size variation, and are recognized by the innate immune system through Toll-like receptors (TLR) 2 and 6. LAMPs can modulate the immune system, and could induce immune cells apoptosis or death. In addition, they may associate with malignant transformation of host cells and are also considered to be cofactors in the progression of AIDS.

Citing Articles

The novel pleuromutilin derivative 22-((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both and .

Xia X, Ji X, Li Y, Wang Y, Zhao Y, Wang W Front Pharmacol. 2025; 15:1491223.

PMID: 39759447 PMC: 11695783. DOI: 10.3389/fphar.2024.1491223.

Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia.

Wang C, Wen J, Yan Z, Zhou Y, Gong Z, Luo Y PLoS Pathog. 2024; 20(11):e1012614.

PMID: 39499730 PMC: 11567624. DOI: 10.1371/journal.ppat.1012614.

Regularity of Toll-Like Receptors in Bovine Mammary Epithelial Cells Induced by .

Yang J, Liu Y, Lin C, Yan R, Li Z, Chen Q Front Vet Sci. 2022; 9:846700.

PMID: 35464378 PMC: 9021453. DOI: 10.3389/fvets.2022.846700.

Host cell interactions of novel antigenic membrane proteins of Mycoplasma agalactiae.

Barbosa M, Marques L, Timenetsky J, Rosengarten R, Spergser J, Chopra-Dewasthaly R BMC Microbiol. 2022; 22(1):93.

PMID: 35395771 PMC: 8991494. DOI: 10.1186/s12866-022-02512-2.

A Review of : A Representative of the Class Associated With Reproductive and Respiratory Disorders in Cattle.

Santos Junior M, Neres N, Campos G, Bastos B, Timenetsky J, Marques L Front Vet Sci. 2021; 8:572171.

PMID: 33681318 PMC: 7930009. DOI: 10.3389/fvets.2021.572171.

References

Rawadi G, Garcia J, Lemercier B, Roman-Roman S . Signal transduction pathways involved in the activation of NF-kappa B, AP-1, and c-fos by Mycoplasma fermentans membrane lipoproteins in macrophages. J Immunol. 1999; 162(4):2193-203. View

Baseman J, Lange M, Criscimagna N, Giron J, Thomas C . Interplay between mycoplasmas and host target cells. Microb Pathog. 1995; 19(2):105-16. DOI: 10.1006/mpat.1995.0050. View

Rock F, Hardiman G, Timans J, Kastelein R, Bazan J . A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A. 1998; 95(2):588-93. PMC: 18464. DOI: 10.1073/pnas.95.2.588. View

Buwitt-Beckmann U, Heine H, Wiesmuller K, Jung G, Brock R, Akira S . Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur J Immunol. 2004; 35(1):282-9. DOI: 10.1002/eji.200424955. View

Takeda K, Akira S . Roles of Toll-like receptors in innate immune responses. Genes Cells. 2001; 6(9):733-42. DOI: 10.1046/j.1365-2443.2001.00458.x. View

Feng S, Tsai S, Rodriguez J, Lo S . Mycoplasmal infections prevent apoptosis and induce malignant transformation of interleukin-3-dependent 32D hematopoietic cells. Mol Cell Biol. 1999; 19(12):7995-8002. PMC: 84884. DOI: 10.1128/MCB.19.12.7995. View

Rawadi G, Roman-Roman S, Castedo M, Dutilleul V, Susin S, Marchetti P . Effects of Mycoplasma fermentans on the myelomonocytic lineage. Different molecular entities with cytokine-inducing and cytocidal potential. J Immunol. 1996; 156(2):670-8. View

Into T, Kiura K, Yasuda M, Kataoka H, Inoue N, Hasebe A . Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation. Cell Microbiol. 2004; 6(2):187-99. DOI: 10.1046/j.1462-5822.2003.00356.x. View

Garcia J, Lemercier B, Roman-Roman S, Rawadi G . A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways. J Biol Chem. 1998; 273(51):34391-8. DOI: 10.1074/jbc.273.51.34391. View

10.

Rawadi G . Mycoplasma fermentans interaction with monocytes/macrophages: molecular basis. Microbes Infect. 2000; 2(8):955-64. DOI: 10.1016/s1286-4579(00)00395-6. View

11.

Muhlradt P, Frisch M . Purification and partial biochemical characterization of a Mycoplasma fermentans-derived substance that activates macrophages to release nitric oxide, tumor necrosis factor, and interleukin-6. Infect Immun. 1994; 62(9):3801-7. PMC: 303034. DOI: 10.1128/iai.62.9.3801-3807.1994. View

12.

Razin S, Yogev D, Naot Y . Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev. 1998; 62(4):1094-156. PMC: 98941. DOI: 10.1128/MMBR.62.4.1094-1156.1998. View

13.

Seya T, Matsumoto M . A lipoprotein family from Mycoplasma fermentans confers host immune activation through Toll-like receptor 2. Int J Biochem Cell Biol. 2002; 34(8):901-6. DOI: 10.1016/s1357-2725(01)00164-9. View

14.

Muhlradt P, Schade U . MDHM, a macrophage-stimulatory product of Mycoplasma fermentans, leads to in vitro interleukin-1 (IL-1), IL-6, tumor necrosis factor, and prostaglandin production and is pyrogenic in rabbits. Infect Immun. 1991; 59(11):3969-74. PMC: 258984. DOI: 10.1128/iai.59.11.3969-3974.1991. View

15.

Akira S, Takeda K, Kaisho T . Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001; 2(8):675-80. DOI: 10.1038/90609. View

16.

Davis K, Wise K . Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans. Infect Immun. 2002; 70(3):1129-35. PMC: 127791. DOI: 10.1128/IAI.70.3.1129-1135.2002. View

17.

Schroder N, Heine H, Alexander C, Manukyan M, Eckert J, Hamann L . Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol. 2004; 173(4):2683-91. DOI: 10.4049/jimmunol.173.4.2683. View

18.

Chambaud I, Wroblewski H, Blanchard A . Interactions between mycoplasma lipoproteins and the host immune system. Trends Microbiol. 1999; 7(12):493-9. DOI: 10.1016/s0966-842x(99)01641-8. View

19.

Horino A, Sasaki Y, Sasaki T, Kenri T . Multiple promoter inversions generate surface antigenic variation in Mycoplasma penetrans. J Bacteriol. 2002; 185(1):231-42. PMC: 141813. DOI: 10.1128/JB.185.1.231-242.2003. View

20.

Into T, Nodasaka Y, Hasebe A, Okuzawa T, Nakamura J, Ohata N . Mycoplasmal lipoproteins induce toll-like receptor 2- and caspases-mediated cell death in lymphocytes and monocytes. Microbiol Immunol. 2002; 46(4):265-76. DOI: 10.1111/j.1348-0421.2002.tb02695.x. View