Molecular Virology of Hepatitis C Virus (HCV): 2006 Update

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2006 Apr 15

PMID 16614739

Citations 31

Authors

Volker Brass

Darius Moradpour

Hubert E Blum

Affiliations

Soon will be listed here.

Abstract

Fascinating progress in the understanding of the molecular biology of hepatitis C virus (HCV) was achieved recently. The replicon system revolutionized the investigation of HCV RNA replication and facilitated drug discovery. Novel systems for functional analyses of the HCV glycoproteins allowed the validation of HCV receptor candidates and the investigation of cell entry mechanisms. Most recently, recombinant infectious HCV could be produced in cell culture, rendering all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In this review, we summarize recent advances and discuss future research directions.

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