Regulation of Ovulation Rate in Mammals: Contribution of Sheep Genetic Models

Overview

Journal Reprod Biol Endocrinol

Publisher Biomed Central

Specialties Endocrinology
Reproductive Medicine

Date 2006 Apr 14

PMID 16611365

Citations 45

Authors

Stephane Fabre

Alice Pierre

Philippe Mulsant

Loys Bodin

Elisa Di Pasquale

Luca Persani

Philippe Monget

Danielle Monniaux

Affiliations

Soon will be listed here.

Abstract

Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate.

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