HuCNS-SC (StemCells)

Overview

Journal Curr Opin Mol Ther

Specialties Molecular Biology
Pharmacology

Date 2006 Apr 14

PMID 16610769

Citations 13

Authors

Philippe Taupin

Affiliations

Soon will be listed here.

Abstract

HuCNS-SC, a proprietary human neural stem cells product, is being developed as a cellular therapy for the potential treatment of Batten disease, one of a group of disorders known as neural ceroid lipofuscinoses (NCL). Developer StemCells is also investigating the therapy for spinal cord injury and other central nervous system disorders, such as demyelinating disease, stroke and Alzheimer's disease. A phase I trial of HuCNS-SC for infantile and late-infantile NCL has been initiated, following the March 2006 U.S. Food and Drug Administration approval of StemCells' investigational new drug application.

Citing Articles

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Concise review: self-renewal in the central nervous system: neural stem cells from embryo to adult.

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Shihabuddin L, Cheng S Neurotherapeutics. 2011; 8(4):659-67.

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Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis.

Lu J, Hu J, Hofmann S Mol Genet Metab. 2009; 99(4):374-8.

PMID: 20036592 PMC: 2839016. DOI: 10.1016/j.ymgme.2009.12.002.