Increased Plasma Nitric Oxide Metabolites in Suicide Attempters

Overview

Journal Neuropsychobiology

Specialty Neurology

Date 2006 Apr 8

PMID 16601363

Citations 19

Authors

Bun-Hee Lee

Sung-Woo Lee

Dokyung Yoon

Heon-Jeong Lee

Jong-Chul Yang

Se-Hoon Shim

Do-Hoon Kim

Seung-Ho Ryu

Changsu Han

Yong-Ku Kim

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NO(x)) and suicide attempt.

Method: Plasma NO(x) levels were measured in 53 patients who had recently attempted suicide, 58 non-suicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale.

Results: Plasma NO(x) levels were significantly higher in suicidal patients than non-suicidal psychiatric patients or normal control subjects (F=11.029, d.f.=2, 183, p<0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003).

Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.

Citing Articles

Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study.

Pang J, Wang Y, Teng H, He J, Luo R, Feng S BMC Psychiatry. 2024; 24(1):249.

PMID: 38565988 PMC: 10988927. DOI: 10.1186/s12888-024-05713-3.

Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide.

Gammoh O, Ibrahim A, Yehya A, Alqudah A, Qnais E, Altaber S Int J Mol Sci. 2024; 25(4).

PMID: 38396638 PMC: 10889164. DOI: 10.3390/ijms25041960.

Vitamins C and D Exhibit Similar Antidepressant Effects to Escitalopram Mediated by NOx and FKBPL in a Stress-Induced Mice Model.

Gammoh O, Ibrahim A, Qnais E, Alqudah A, Altaber S, Aljabali A Nutrients. 2023; 15(12).

PMID: 37375593 PMC: 10302470. DOI: 10.3390/nu15122692.

The Tryptophan Catabolite or Kynurenine Pathway in a Major Depressive Episode with Melancholia, Psychotic Features and Suicidal Behaviors: A Systematic Review and Meta-Analysis.

Almulla A, Thipakorn Y, Vasupanrajit A, Tunvirachaisakul C, Oxenkrug G, Al-Hakeim H Cells. 2022; 11(19).

PMID: 36231075 PMC: 9563030. DOI: 10.3390/cells11193112.

A network pharmacology approach to predict potential targets and mechanisms of "" herb pair in the treatment of chronic pain with comorbid anxiety and depression.

Pan H, Xi Z, Wei X, Wang K Ann Med. 2022; 54(1):413-425.

PMID: 35098831 PMC: 8812742. DOI: 10.1080/07853890.2022.2031268.