Analysis of Human Antibodies to Erythrocyte Binding Antigen 175 Peptide 4 of Plasmodium Falciparum

Overview

Journal Clin Med Res

Specialty General Medicine

Date 2006 Apr 6

PMID 16595787

Citations 12

Authors

Fousseyni S Toure

Philippe Deloron

Florence Migot-Nabias

Affiliations

Soon will be listed here.

Abstract

Background: The IgG1 and IgG3 antibodies are considered cytophilic and protective against Plasmodium falciparum, whereas IgG2 and IgG4 are thought to block protective mechanisms.

Objectives: The main objective was to measure antibodies directed against erythrocyte binding antigen-175 (EBA-175) peptide 4 and analyze the relationship between such antibodies and clinical malaria attack.

Methods: Using an enzyme-linked immunosorbent assay, a retrospective analysis of naturally acquired antibodies to synthetic peptide from EBA-175 peptide 4 has been carried out in 158 school children from the village of Dienga in Gabon.

Results: The overall prevalence rates of antibodies to EBA-175 peptide 4 were 85.2%, 66.8%, 52.6%, 71.6% and 64.0% for total IgG, IgG1, IgG2, IgG3 and IgG4, respectively. Protection from clinical malaria, determined after a prospective 1-year study, was associated with the levels of IgG and IgG1 antibodies that increased with age.

Conclusion: Together, these data suggest that age/exposure-related acquisition of anti-EBA-175 antibodies may contribute to the development of clinically protective immunity and could be taken into account in malaria control strategies when they are confirmed.

Citing Articles

Characterization of anti-EBA175RIII-V in asymptomatic adults and children living in communities in the Greater Accra Region of Ghana with varying malaria transmission intensities.

Amoah L, Abagna H, Akyea-Mensah K, Lo A, Kusi K, Gyan B BMC Immunol. 2018; 19(1):34.

PMID: 30453898 PMC: 6245760. DOI: 10.1186/s12865-018-0271-y.

High Level of Specific Anti- Merozoite IgG1 Antibodies in Rural Asymptomatic Individuals of Dienga, South-Eastern Gabon.

Pegha-Moukandja I, Imboumy-Limoukou R, Tchitoula-Makaya N, Mouinga-Ondeme A, Biteghe-Bi-Essone J, Mba D Eur J Microbiol Immunol (Bp). 2018; 7(4):247-260.

PMID: 29403652 PMC: 5793693. DOI: 10.1556/1886.2017.00010.

Assessment of the quality and quantity of naturally induced antibody responses to EBA175RIII-V in Ghanaian children living in two communities with varying malaria transmission patterns.

Abagna H, Acquah F, Okonu R, Aryee N, Theisen M, Amoah L Malar J. 2018; 17(1):14.

PMID: 29310662 PMC: 5759240. DOI: 10.1186/s12936-017-2167-3.

Synthetic Antigens Derived from Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area.

Pratt-Riccio L, Perce-da-Silva D, Lima-Junior J, Riccio E, Ribeiro-Alves M, Santos F Am J Trop Med Hyg. 2017; 97(5):1581-1592.

PMID: 29016339 PMC: 5817778. DOI: 10.4269/ajtmh.17-0359.

Variations in the quality of malaria-specific antibodies with transmission intensity in a seasonal malaria transmission area of Northern Ghana.

Kusi K, Manu E, Gwira T, Kyei-Baafour E, Dickson E, Amponsah J PLoS One. 2017; 12(9):e0185303.

PMID: 28945794 PMC: 5612719. DOI: 10.1371/journal.pone.0185303.

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