NFkappaB in Neurons? The Uncertainty Principle in Neurobiology

Overview

Journal J Neurochem

Specialties Chemistry
Neurology

Date 2006 Apr 1

PMID 16573643

Citations 23

Authors

Paul T Massa

Hossein Aleyasin

David S Park

Xianrong Mao

Steven W Barger

Affiliations

Soon will be listed here.

Abstract

Nuclear factor kappaB (NFkappaB) is a dynamically modulated transcription factor with an extensive literature pertaining to widespread actions across species, cell types and developmental stages. Analysis of NFkappaB in a complex environment such as neural tissue suffers from a difficulty in simultaneously establishing both activity and location. Much of the available data indicate a profound recalcitrance of NFkappaB activation in neurons, as compared with most other cell types. Few studies to date have sought to distinguish between the various combinatorial dimers of NFkappaB family members. Recent research has illuminated the importance of these problems, as well as opportunities to move past them to the nuances manifest through variable activation pathways, subunit complexity and target sequence preferences.

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