Murine Cytomegalovirus Interference with Antigen Presentation Contributes to the Inability of CD8 T Cells to Control Virus in the Salivary Gland

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2006 Mar 31

PMID 16571839

Citations 26

Authors

Xiuju Lu

Amelia K Pinto

Ann M Kelly

Kathy S Cho

Ann B Hill

Affiliations

Soon will be listed here.

Abstract

Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMV's known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells' inability to control virus in the salivary gland.

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