Comparative Genomic Hybridisation in Malignant Deciduoid Mesothelioma

Overview

Journal J Clin Pathol

Specialty Pathology

Date 2006 Mar 30

PMID 16569690

Citations 3

Authors

A Scattone

A Pennella

M Gentile

M Musti

P Nazzaro

A L Buonadonna

A Marzullo

D Cavone

L Pollice

G Serio

Affiliations

Soon will be listed here.

Abstract

Background: Malignant deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. This tumour generally has poor prognosis, and can be asbestos related.

Aim: To identify peculiar genetic changes responsible for critical phases in pathogenesis of malignant deciduoid mesothelioma and their prognostic relevance.

Methods: Comparative genomic hybridisation was carried out in six cases of malignant pleural deciduoid mesothelioma, four sporadic and two familial. All cases were found to be asbestos related. Four patients died during follow-up and the mean survival was 29.5 (SD 14.2, range 12-43) months.

Results: Genetic abnormalities were found in all the tumour tissues, the most frequent being chromosomal gains at 1p, 12q, 17, 8q, 19 and 20 and losses at 13q, 6q and 9p. Survival was found to be longer in those patients who presented a smaller number of losses (< or =2) in the tumorous chromosomes.

Conclusions: Although numerous genetic changes are presented by deciduoid mesotheliomas, certain chromosomal regions are preferentially affected. The clinical outcome for this mesothelioma subtype is predicted by the number of losses.

Citing Articles

Malignant Pleural Mesothelioma: Genetic and Microenviromental Heterogeneity as an Unexpected Reading Frame and Therapeutic Challenge.

Abbott D, Bortolotto C, Benvenuti S, Lancia A, Filippi A, Stella G Cancers (Basel). 2020; 12(5).

PMID: 32392897 PMC: 7281319. DOI: 10.3390/cancers12051186.

Deciduoid type malignant pleural mesothelioma: a case report.

Okita R, Nojima Y, Saisho S, Shimizu K, Shirai R, Kanomata N AME Case Rep. 2018; 2:43.

PMID: 30506035 PMC: 6232047. DOI: 10.21037/acr.2018.09.02.

Metastasis of a pleural mesothelioma to a hyperplastic stomach polyp: an increase of vimentin expression is seen during a gain in deciduoid morphology.

Soltermann A, Pache J, Vogt P Rare Tumors. 2012; 3(4):e52.

PMID: 22355507 PMC: 3282457. DOI: 10.4081/rt.2011.e52.

References

De Rienzo A, Jhanwar S, Testa J . Loss of heterozygosity analysis of 13q and 14q in human malignant mesothelioma. Genes Chromosomes Cancer. 2000; 28(3):337-41. View

Cher M, MacGrogan D, Bookstein R, Brown J, Jenkins R, Jensen R . Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer. Genes Chromosomes Cancer. 1994; 11(3):153-62. DOI: 10.1002/gcc.2870110304. View

Chen C, Brabham W, Stultz B, Frierson Jr H, Barrett J, Sawyers C . Defining a common region of deletion at 13q21 in human cancers. Genes Chromosomes Cancer. 2001; 31(4):333-44. DOI: 10.1002/gcc.1152. View

Serio G, Scattone A, Pennella A, Giardina C, Musti M, Valente T . Malignant deciduoid mesothelioma of the pleura: report of two cases with long survival. Histopathology. 2002; 40(4):348-52. DOI: 10.1046/j.1365-2559.2002.01373.x. View

Shanks J, Harris M, Banerjee S, Eyden B, Joglekar V, Nicol A . Mesotheliomas with deciduoid morphology: a morphologic spectrum and a variant not confined to young females. Am J Surg Pathol. 2000; 24(2):285-94. DOI: 10.1097/00000478-200002000-00015. View

Desai S, Kane S, Bharde S, Kulkarni J, Soman C . Malignant peritoneal mesothelioma deciduoid or anaplastic variant? Point to ponder. Indian J Pathol Microbiol. 2002; 44(2):159-62. View

Gillespie F, van der Walt J, Derias N, Kenney A . Deciduoid peritoneal mesothelioma. A report of the cytological appearances. Cytopathology. 2001; 12(1):57-61. DOI: 10.1046/j.1365-2303.2001.00294.x. View

Taguchi T, Jhanwar S, Siegfried J, Keller S, Testa J . Recurrent deletions of specific chromosomal sites in 1p, 3p, 6q, and 9p in human malignant mesothelioma. Cancer Res. 1993; 53(18):4349-55. View

Okonkwo A, Musunuri S, Diaz Jr L, Bedrossian C, STRYKER S, Rao S . Deciduoid mesothelioma: a rare, distinct entity with unusual features. Ann Diagn Pathol. 2001; 5(3):168-71. DOI: 10.1053/adpa.2001.25410. View

10.

Puttagunta L, Vriend R, Nguyen G . Deciduoid epithelial mesothelioma of the pleura with focal rhabdoid change. Am J Surg Pathol. 2000; 24(10):1440-3. DOI: 10.1097/00000478-200010000-00021. View

11.

Talerman A, Montero J, Chilcote R, Okagaki T . Diffuse malignant peritoneal mesothelioma in a 13-year-old girl. Report of a case and review of the literature. Am J Surg Pathol. 1985; 9(1):73-80. DOI: 10.1097/00000478-198501000-00012. View

12.

Ried T, Petersen I, Holtgreve-Grez H, Speicher M, Schrock E, Du Manoir S . Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization. Cancer Res. 1994; 54(7):1801-6. View

13.

Talerman A . Deciduoid or pseudodecidual mesothelioma. Am J Surg Pathol. 2000; 24(8):1179. DOI: 10.1097/00000478-200008000-00029. View

14.

Ascoli V, Aalto Y, Carnovale-Scalzo C, Nardi F, Falzetti D, Mecucci C . DNA copy number changes in familial malignant mesothelioma. Cancer Genet Cytogenet. 2001; 127(1):80-2. DOI: 10.1016/s0165-4608(00)00420-9. View

15.

BELL D, Jhanwar S, Testa J . Multiple regions of allelic loss from chromosome arm 6q in malignant mesothelioma. Cancer Res. 1997; 57(18):4057-62. View

16.

De Rienzo A, Balsara B, Apostolou S, Jhanwar S, Testa J . Loss of heterozygosity analysis defines a 3-cM region of 15q commonly deleted in human malignant mesothelioma. Oncogene. 2001; 20(43):6245-9. DOI: 10.1038/sj.onc.1204828. View

17.

Serio G, Scattone A, Gentile M, Nazzaro P, Pennella A, Buonadonna A . Familial pleural mesothelioma with environmental asbestos exposure: losses of DNA sequences by comparative genomic hybridization (CGH). Histopathology. 2004; 45(6):643-5. DOI: 10.1111/j.1365-2559.2004.01941.x. View

18.

Kallioniemi A, Kallioniemi O, Piper J, Tanner M, Stokke T, Chen L . Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A. 1994; 91(6):2156-60. PMC: 43329. DOI: 10.1073/pnas.91.6.2156. View

19.

Murthy S, Testa J . Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma. J Cell Physiol. 1999; 180(2):150-7. DOI: 10.1002/(SICI)1097-4652(199908)180:2<150::AID-JCP2>3.0.CO;2-H. View

20.

Orosz Z, Nagy P, Szentirmay Z, Zalatnai A, Hauser P . Epithelial mesothelioma with deciduoid features. Virchows Arch. 1999; 434(3):263-6. DOI: 10.1007/s004280050339. View