Dense-core Secretory Granule Biogenesis

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2006 Mar 28

PMID 16565478

Citations 106

Authors

Taeyoon Kim

Marjorie C Gondre-Lewis

Irina Arnaoutova

Y Peng Loh

Affiliations

Soon will be listed here.

Abstract

The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.

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