Enhancement of Primary Antigen-specific Resistance in Infant Mice with Divinyl Ether-maleic Anhydride

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1974 Nov 1

PMID 16558084

Citations 3

Authors

J Y Richmond

C H CAMPBELL

Affiliations

Soon will be listed here.

Abstract

The early response of infant mice to foot-and-mouth disease viral antigens, measured by greater resistance and increased serum-neutralizing antibody, was enhanced by divinyl ether-maleic anhydride (DVE/MA). Preparations of known antigen concentration were used to study various parameters influencing this enhancement. Resistance and antibody levels were increased when DVE/MA was administered with aqueous or oil-emulsified antigens, whether given separately or mixed with the antigens, but was dependent on the dose and route of the DVE/MA and antigen. Enhanced resistance developed rapidly, was antigen-specific, and may have been related to the level of neutralizing antibody.

Citing Articles

Studies with divinyl ether-maleic anhydride and foot-and-mouth disease vaccines in swine.

CAMPBELL C, Richmond J, McKERCHER P Arch Gesamte Virusforsch. 1974; 46(3-4):334-40.

PMID: 4375451 DOI: 10.1007/BF01240075.

Interferon inducers and foot-and-mouth disease vaccines: influence of two synthetic polynucleotides on antibody response and immunity in guinea pigs and swine.

Cunliffe H, Richmond J, CAMPBELL C Can J Comp Med. 1977; 41(1):117-21.

PMID: 188530 PMC: 1277702.

Production, isolation, and partial characterization of three foot-and-mouth disease virus temperature-sensitive mutants.

Richmond J Infect Immun. 1975; 11(6):1291-5.

PMID: 166915 PMC: 415213. DOI: 10.1128/iai.11.6.1291-1295.1975.

References

Chester T, De Clercq E, Merigan T . Effect of Separate and Combined Injections of Poly rI: Poly rC and Endotoxin on Reticulo-endothelial Activity, Interferon, and Antibody Production in the Mouse. Infect Immun. 1971; 3(4):516-20. PMC: 416187. DOI: 10.1128/iai.3.4.516-520.1971. View

CAMPBELL C . Influence of litter size, age, variation, and selective breeding of mice on susceptibility to foot-and-mouth disease virus. Am J Vet Res. 1968; 29(3):685-91. View

Braun W, Nakano M . Antibody formation: stimulation by polyadenylic and polycytidylic acids. Science. 1967; 157(3790):819-21. DOI: 10.1126/science.157.3790.819. View

Polatnick J, Bachrach H . PRODUCTION AND PURIFICATION OF MILLIGRAM AMOUNTS OF FOOT-AND-MOUTH DISEASE VIRUS FROM BABY HAMSTER KIDNEY CELL CULTURES. Appl Microbiol. 1964; 12:368-73. PMC: 1058135. DOI: 10.1128/am.12.4.368-373.1964. View

Wagner G, Card J, Cowan K . Immunochemical studies of foot-and-mouth disease. VII. Characterization of foot-and-mouth disease virus concentrated by polyethylene glycol precipitation. Arch Gesamte Virusforsch. 1970; 30(4):343-52. DOI: 10.1007/BF01258364. View

Billiau A, Muyembe J, DE SOMER P . Mechanism of antiviral activity in vivo of polycarboxylases which induce interferon production. Nat New Biol. 1971; 232(2):183-6. DOI: 10.1038/newbio232183a0. View

GRAVES J, McKERCHER P, Callis J . Foot-and-mouth disease vaccine: influence of the vaccine virus subtype on neutralizing antibody and resistance to disease. Am J Vet Res. 1972; 33(4):765-8. View

Richmond J, CAMPBELL C . Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: effect on adsorption and multiplication in mouse tissues. Arch Gesamte Virusforsch. 1972; 36(3):232-9. DOI: 10.1007/BF01249854. View

CAMPBELL C, Richmond J . Enhancement, by two carboxylic acid interferon inducers of resistance stimulated in mice by foot-and-mouth disease vaccine. Infect Immun. 1973; 7(2):199-204. PMC: 422660. DOI: 10.1128/iai.7.2.199-204.1973. View

10.

Pindak F, Schmidt J, Giron D, Allen P . Interferon levels and resistance to viral infection associated with selected interferon inducers. Proc Soc Exp Biol Med. 1971; 138(1):317-21. DOI: 10.3181/00379727-138-35887. View

11.

Merigan T, Finkelstein M . Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. Virology. 1968; 35(3):363-74. DOI: 10.1016/0042-6822(68)90215-8. View

12.

DIAMANTSTEIN T, Ruhl H, VOGT W, Bochert G . Stimulation of B-cells by dextran sulphate in vitro. Immunology. 1973; 25(4):743-7. PMC: 1423138. View

13.

Morahan P, Regelson W, MUNSON A . Pyran and polyribonucleotides: differences in biological activities. Antimicrob Agents Chemother. 1972; 2(1):16-22. PMC: 444259. DOI: 10.1128/AAC.2.1.16. View

14.

Cone R, Johnson A . Regulation of the immune system by synthetic polynucleotides. 3. Action on antigen-reactive cells of thymic origin. J Exp Med. 1971; 133(3):665-76. PMC: 2138952. DOI: 10.1084/jem.133.3.665. View

15.

MUNSON A, Regelson W, LAWRENCE Jr W, WOOLES W . Biphasic response of the reticuloendothelial system (RES) induced by pyran copolymer. J Reticuloendothel Soc. 1970; 7(3):375-85. View

16.

DIAMANTSTEIN T, Wagner B, Beyse I, Odenwald M . [Mechanism of stimulation of humoral antibody formation by polyanions]. Z Klin Chem Klin Biochem. 1970; 8(6):632-6. View

17.

Braun W, Regelson W, Yajima Y, Ishizuka M . Stimulation of antibody formation by pyran copolymer. Proc Soc Exp Biol Med. 1970; 133(1):171-5. DOI: 10.3181/00379727-133-34433. View

18.

Richmond J . Mouse Resistance Against Foot-and-Mouth Disease Virus Induced by Injections of Pyran. Infect Immun. 1971; 3(2):249-53. PMC: 416139. DOI: 10.1128/iai.3.2.249-253.1971. View