Resistance Factor-mediated Spectinomycin Resistance

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1970 Jan 1

PMID 16557684

Citations 4

Authors

D H Smith

J A Janjigian

N Prescott

P W Anderson

Affiliations

Soon will be listed here.

Abstract

Of 100 natural isolates of drug-resistant enteric bacteria, 51 were resistant to spectinomycin (Spc) and 46 contained transferable R factors mediating Spc resistance. All Spc(R) R factors mediated streptomycin and bluensomycin resistance and were fi(+) type. Extracts of R-Spc(R) strains adenylated Spc, dihydrospectinomycin, actinamine, streptomycin, and bluensomycin in vitro in the presence of adenosine triphosphate and Mg(++). Results of genetic and biochemical studies support the hypothesis that these reactions are mediated by a single enzyme.

Citing Articles

Inactivation of dihydrostreptomycin and spectinomycin by Staphylococcus aureus.

Kawabe H, Inoue M, Mitsuhashi S Antimicrob Agents Chemother. 1974; 5(6):553-7.

PMID: 15825403 PMC: 429012. DOI: 10.1128/AAC.5.6.553.

Genetic map of the crown gall suppressive IncW plasmid pSa.

Tait R, Lundquist R, Kado C Mol Gen Genet. 1982; 186(1):10-5.

PMID: 6287164 DOI: 10.1007/BF00422905.

Derivatives of 4-dihydro-4-deoxy-4(R)-amino spectinomycin and their activity against susceptible and resistant Escherichia coli strains.

Werner R, Lechner U, Goeth H Antimicrob Agents Chemother. 1982; 21(1):101-6.

PMID: 6282201 PMC: 181835. DOI: 10.1128/AAC.21.1.101.

Mutations in Escherichia coli K-12 decreasing the rate of streptomycin uptake: synergism with R-factor-mediated capacity to inactivate streptomycin.

Lundback A, Nordstrom K Antimicrob Agents Chemother. 1974; 5(5):500-7.

PMID: 4618460 PMC: 429002. DOI: 10.1128/AAC.5.5.500.

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