Vietnam Military Service History and Prostate Cancer

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2006 Mar 25

PMID 16556325

Citations 12

Authors

Justine Leavy

Gina Ambrosini

Lin Fritschi

Affiliations

Soon will be listed here.

Abstract

Background: Three decades after US and Australian forces withdrew from Vietnam, there has been much public interest in the health consequences of service in Vietnam. One controversial question is whether the risk of prostate cancer amongst Vietnam veterans is increased. This paper examines relationships between military history, family history and risk of prostate cancer in a population-based case control study.

Methods: Cases were selected from the Cancer Registry of Western Australia as incident cases of histologically-confirmed prostate cancer, and controls were age-matched and selected from the Western Australian electoral roll. Study participants were asked to report any military service history and details about that service.

Results: Between January 2001 and September 2002, 606 cases and 471 controls aged between 40-75 years were recruited. An increased prostate cancer risk was observed in men reporting they were deployed in Vietnam although this was not statistically significant (OR = 2.12; 95% CI 0.88-5.06). An increased risk was also observed in men reporting prostate cancer in fathers (OR = 1.90; 95% CI 1.20-3.00) or brothers (OR = 2.05; 95% CI 1.20-3.50) diagnosed with prostate cancer.

Conclusion: These findings support a positive association between prostate cancer and military service history in the Vietnam war and a first degree relative family history of prostate cancer.

Citing Articles

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Differences in the prevalence of modifiable risk and protective factors for prostate cancer by race and ethnicity in the National Health and Nutrition Examination Survey.

Defever K, Platz E, Lopez D, Mondul A Cancer Causes Control. 2020; 31(9):851-860.

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Usual adult occupation and risk of prostate cancer in West African men: the Ghana Prostate Study.

Adler C, Friesen M, Yeboah E, Tettey Y, Biritwum R, Adjei A Occup Environ Med. 2018; 76(2):71-77.

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Prostate cancer surveillance by occupation and industry: the Canadian Census Health and Environment Cohort (CanCHEC).

Sritharan J, Macleod J, Harris S, Cole D, Harris A, Tjepkema M Cancer Med. 2018; 7(4):1468-1478.

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Prostate cancer in firefighting and police work: a systematic review and meta-analysis of epidemiologic studies.

Sritharan J, Pahwa M, Demers P, Harris S, Cole D, Parent M Environ Health. 2017; 16(1):124.

PMID: 29149887 PMC: 5693511. DOI: 10.1186/s12940-017-0336-z.

References

Zafar M, Terris M . Prostate cancer detection in veterans with a history of Agent Orange exposure. J Urol. 2001; 166(1):100-3. View

Lesko S, Rosenberg L, Shapiro S . Family history and prostate cancer risk. Am J Epidemiol. 1996; 144(11):1041-7. DOI: 10.1093/oxfordjournals.aje.a008876. View

Stanford J, Ostrander E . Familial prostate cancer. Epidemiol Rev. 2001; 23(1):19-23. DOI: 10.1093/oxfordjournals.epirev.a000789. View

Staples M, Giles G, English D, McCredie M, Severi G, Cui J . Risk of prostate cancer associated with a family history in an era of rapid increase in prostate cancer diagnosis (Australia). Cancer Causes Control. 2003; 14(2):161-6. DOI: 10.1023/a:1023073203467. View

Giles G, Severi G, English D, McCredie M, Borland R, Boyle P . Sexual factors and prostate cancer. BJU Int. 2003; 92(3):211-6. DOI: 10.1046/j.1464-410x.2003.04319.x. View

Frumkin H . Agent Orange and cancer: an overview for clinicians. CA Cancer J Clin. 2003; 53(4):245-55. DOI: 10.3322/canjclin.53.4.245. View

Gaff C, Aragona C, MacInnis R, Cowan R, Payne C, Giles G . Accuracy and completeness in reporting family history of prostate cancer by unaffected men. Urology. 2004; 63(6):1111-6. DOI: 10.1016/j.urology.2003.12.032. View

. Postservice mortality among Vietnam veterans. The Centers for Disease Control Vietnam Experience Study. JAMA. 1987; 257(6):790-5. View

Fett M, NAIRN J, Cobbin D, Adena M . Mortality among Australian conscripts of the Vietnam conflict era. II. Causes of death. Am J Epidemiol. 1987; 125(5):878-84. DOI: 10.1093/oxfordjournals.aje.a114604. View

10.

. Health status of Vietnam veterans. II. Physical Health. The Centers for Disease Control Vietnam Experience Study. JAMA. 1988; 259(18):2708-14. View

11.

Hall W . The logic of a controversy: the case of Agent Orange in Australia. Soc Sci Med. 1989; 29(4):537-44. DOI: 10.1016/0277-9536(89)90199-8. View

12.

DECOUFLE P, Holmgreen P, Boyle C, Stroup N . Self-reported health status of Vietnam veterans in relation to perceived exposure to herbicides and combat. Am J Epidemiol. 1992; 135(3):312-23. DOI: 10.1093/oxfordjournals.aje.a116285. View

13.

Schecter A, Dai L, Thuy L, Quynh H, Minh D, Cau H . Agent Orange and the Vietnamese: the persistence of elevated dioxin levels in human tissues. Am J Public Health. 1995; 85(4):516-22. PMC: 1615128. DOI: 10.2105/ajph.85.4.516. View

14.

Whittemore A, Wu A, Kolonel L, John E, Gallagher R, Howe G . Family history and prostate cancer risk in black, white, and Asian men in the United States and Canada. Am J Epidemiol. 1995; 141(8):732-40. DOI: 10.1093/oxfordjournals.aje.a117495. View

15.

OToole B, Marshall R, Grayson D, Schureck R, Dobson M, Ffrench M . The Australian Vietnam Veterans Health Study: II. self-reported health of veterans compared with the Australian population. Int J Epidemiol. 1996; 25(2):319-30. DOI: 10.1093/ije/25.2.319. View

16.

Kang H, Dalager N, Needham L, Patterson Jr D, Matanoski G, Kanchanaraksa S . US Army Chemical Corps Vietnam veterans health study: preliminary results. Chemosphere. 2001; 43(4-7):943-9. DOI: 10.1016/s0045-6535(00)00455-0. View

17.

Clapp R . Update of cancer surveillance of veterans in Massachusetts, USA. Int J Epidemiol. 1997; 26(3):679-81. DOI: 10.1093/ije/26.3.679. View

18.

Gronberg H, ISAACS S, Smith J, Carpten J, Bova G, Freije D . Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus. JAMA. 1997; 278(15):1251-5. DOI: 10.1001/jama.1997.03550150055035. View

19.

Threlfall T, English D, Rouse I . Prostate cancer in Western Australia: trends in incidence and mortality from 1985 to 1996. Med J Aust. 1998; 169(1):21-4. DOI: 10.5694/j.1326-5377.1998.tb141472.x. View

20.

Fujikawa K, Sasaki M, Arai Y, Yamabe H, Ogawa O, Yoshida O . Prognostic criteria in patients with prostate cancer: Gleason score versus volume-weighted mean nuclear volume. Clin Cancer Res. 1997; 3(4):613-8. View