Reduced E-cadherin and Alpha-catenin Expressions Have No Prognostic Role in Bladder Carcinoma
Overview
Authors
Affiliations
In various human cancers, dysfunction of the E-cadherin-catenin complex is associated with a decrease in cellular and tissue differentiation, and with higher invasive and metastatic potentials. The objective of this study was to investigate E-cadherin and alpha-catenin expression in superficial noninvasive papillary TCC and invasive TCC, and correlate these results with pathological and clinical parameters. We have used immunohistochemistry to localize Ecadherin and alpha-catenin in 56 formalin-fixed, paraffin-embedded tissue blocks from 41 patients with superficial bladder cancer and 15 with invasive bladder cancer. The 46 male and 10 female patients had a mean age of 67 years, with range of 40 to 82 years. The mean follow-up time was 33.4 (range 5-120) months. Tumor grade 1:2:3 ratios were 5:32:19. In superficial bladder tumor, abnormal expression of E-cadherin and alpha-catenin was demonstrated in 37 and 71% of the tumors, respectively. In advanced bladder tumor, abnormal expression of E-cadherin and alpha-catenin was demonstrated in 80 and 100% of the tumors, respectively. Differences in expression of E-cadherin and alpha-catenin could be discerned between superficial and advanced bladder tumors (p=0.004, p=0.024, respectively). However, the association between E-cadherin and alpha-catenin expression and tumor grade was not statistically significant (p>0.05). In addition, the expression of E-cadherin and alpha-catenin did not correlate with tumor number and size (p>0.05). We have demonstrated that abnormal expression of E-cadherin and/or alpha-catenin occurs in more than 85% of bladder carcinomas and correlates significantly only with advanced stage. Nevertheless, these observations need to be confirmed in larger prospective clinical studies.
Cin M, Akyildiz Igdem A, Bektas S, Gundogar O, Cin S, Komut N Diagnostics (Basel). 2024; 14(20).
PMID: 39451592 PMC: 11506668. DOI: 10.3390/diagnostics14202270.
Predictive value of β-catenin in bladder cancer: a systematic review and meta-analysis.
Ren J, Yang Y, Peng T, Xu D Biosci Rep. 2020; 40(9).
PMID: 32797169 PMC: 7475297. DOI: 10.1042/BSR20202127.
Hussein S, Mosaad H, Rashed H, Ahmed S, Ragab A, Ismail E Mol Biol Rep. 2017; 44(4):365-377.
PMID: 28808805 DOI: 10.1007/s11033-017-4118-z.
Breyer J, Gierth M, Shalekenov S, Aziz A, Schafer J, Burger M World J Urol. 2015; 34(5):709-16.
PMID: 26394624 DOI: 10.1007/s00345-015-1690-5.
Role of β-catenin in post-meiotic male germ cell differentiation.
Chang Y, Lee-Chang J, Harris K, Sinha-Hikim A, Rao M PLoS One. 2011; 6(11):e28039.
PMID: 22125654 PMC: 3220672. DOI: 10.1371/journal.pone.0028039.