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Reduced E-cadherin and Alpha-catenin Expressions Have No Prognostic Role in Bladder Carcinoma

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Specialty Oncology
Date 2006 Mar 24
PMID 16554911
Citations 8
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Abstract

In various human cancers, dysfunction of the E-cadherin-catenin complex is associated with a decrease in cellular and tissue differentiation, and with higher invasive and metastatic potentials. The objective of this study was to investigate E-cadherin and alpha-catenin expression in superficial noninvasive papillary TCC and invasive TCC, and correlate these results with pathological and clinical parameters. We have used immunohistochemistry to localize Ecadherin and alpha-catenin in 56 formalin-fixed, paraffin-embedded tissue blocks from 41 patients with superficial bladder cancer and 15 with invasive bladder cancer. The 46 male and 10 female patients had a mean age of 67 years, with range of 40 to 82 years. The mean follow-up time was 33.4 (range 5-120) months. Tumor grade 1:2:3 ratios were 5:32:19. In superficial bladder tumor, abnormal expression of E-cadherin and alpha-catenin was demonstrated in 37 and 71% of the tumors, respectively. In advanced bladder tumor, abnormal expression of E-cadherin and alpha-catenin was demonstrated in 80 and 100% of the tumors, respectively. Differences in expression of E-cadherin and alpha-catenin could be discerned between superficial and advanced bladder tumors (p=0.004, p=0.024, respectively). However, the association between E-cadherin and alpha-catenin expression and tumor grade was not statistically significant (p>0.05). In addition, the expression of E-cadherin and alpha-catenin did not correlate with tumor number and size (p>0.05). We have demonstrated that abnormal expression of E-cadherin and/or alpha-catenin occurs in more than 85% of bladder carcinomas and correlates significantly only with advanced stage. Nevertheless, these observations need to be confirmed in larger prospective clinical studies.

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References
1.
NARAYANA A, Loening S, Slymen D, Culp D . Bladder cancer: factors affecting survival. J Urol. 1983; 130(1):56-60. DOI: 10.1016/s0022-5347(17)50952-0. View

2.
Landis S, Murray T, Bolden S, Wingo P . Cancer statistics, 1999. CA Cancer J Clin. 1999; 49(1):8-31, 1. DOI: 10.3322/canjclin.49.1.8. View

3.
Lipponen P . Review of cytometric methods in the assessment of prognosis in transitional cell bladder cancer. Eur Urol. 1992; 21(3):177-83. DOI: 10.1159/000474833. View

4.
Thrasher J, Crawford E . Current management of invasive and metastatic transitional cell carcinoma of the bladder. J Urol. 1993; 149(5):957-72. DOI: 10.1016/s0022-5347(17)36270-5. View

5.
Millan-Rodriguez F, Salvador-Bayarri J, Palou J, Vicente-Rodriguez J . Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J Urol. 1999; 163(1):73-8. DOI: 10.1016/s0022-5347(05)67975-x. View