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In Vitro Comparison of Cilofungin Alone and in Combination with Other Antifungal Agents Against Clinical Isolates of Candida Species

Overview
Journal Eur J Clin Microbiol Infect Dis
Publisher Springer
Specialties Infectious Diseases
Microbiology
Date 1991 Jul 1
PMID 1655435
Citations 4
Authors
K R Smith
K M Lank
W E Dismukes
C G Cobbs
Affiliations
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Abstract

Cilofungin, a lipopeptide antifungal agent, was tested for in vitro activity alone and in combination with ketoconazole, itraconazole, flucytosine and amphotericin B against 102 clinical isolates of Candida species. At 48 hours all isolates of Candida albicans, Candida tropicalis, Candida paratropicalis and Candida glabrata were inhibited by less than or equal to 5 meg/ml of cilofungin. In contrast, the MIC90 for Candida krusei was 10 mcg/ml and for Candida parapsilosis greater than 40 mcg/ml. The interaction of combinations of cilofungin with amphotericin B, itraconazole, ketoconazole and flucytosine was additive or indifferent at 48 hours for 100%, 88%, 78% and 70% of all Candida species isolates, respectively. Overall, cilofungin demonstrated good activity in vitro against most Candida species isolates.

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